University of Missouri, Columbia, MO, Baton Rouge, LA, USA.
Atherosclerosis. 2012 Nov;225(1):154-9. doi: 10.1016/j.atherosclerosis.2012.08.013. Epub 2012 Sep 16.
The purpose of this study was to investigate the vasodilatory and vasoconstrictor responses of the brachial artery in patients with chronic heart failure (CHF) and controls (CON) before and after a period of training and detraining.
CHF (n = 10; age = 62 ± 8 yrs) and CON (n = 10; age = 55 ± 5 yrs) subjects completed 4 weeks of bilateral handgrip training (20 min; 60% of maximal handgrip strength; 15 gripsmin(-1); 4 daysweek(-1)). Handgrip strength was measured using a hand dynamometer. Brachial artery flow-mediated dilation (BAFMD) and cold pressor test (CPT) responses were determined using ultrasonography prior to training, at the end of 4 weeks of training and following 4 weeks of detraining. Absolute (mm) BAFMD and CPT responses were combined to yield a vascular operating range (VOR).
Baseline BAFMD was higher in CON (CHF: 2.98 ± 1.49%; CON: 6.21 ± 1.21%; p = 0.01), while CPT responses were higher in CHF (CHF: 3.38 ± 0.83%; CON: 2.46 ± 0.62%; p = 0.05). Baseline VOR tended to be greater in the CON subjects (CHF: 0.28 ± 0.05 mm; CON: 0.32 ± 0.12 mm; p = 0.06). Training increased handgrip strength (∼5%; p < 0.05, for both groups), BAFMD (CHF: 2.98 ± 1.49% to 3.75 ± 1.56%; CON: 6.21 ± 1.21% - 8.02 ± 1.75%; p = 0.01) and VOR (CHF: 0.28 ± 0.05 mm - 0.3 ± 0.09 mm; CON: 0.32 ± 0.12 mm - 0.42 ± 0.11 mm; p = 0.01). There were no significant changes in CPT responses. All markers approached pre-training values following detraining.
Handgrip exercise increases strength, BAFMD and VOR in both CHF and CON subjects. These improvements are transient and return to pre-training values after removal of the training stimulus.
本研究旨在探讨慢性心力衰竭（CHF）患者和对照组（CON）患者在训练和脱训前后肱动脉的血管舒张和收缩反应。
CHF 组（n=10；年龄 62±8 岁）和 CON 组（n=10；年龄 55±5 岁）受试者完成了 4 周的双侧握力训练（20 分钟；最大握力的 60%；15 次握力*分钟^(-1)；每周 4 天）。使用握力计测量握力。在训练前、4 周训练结束时和 4 周脱训后，使用超声检查肱动脉血流介导的扩张（BAFMD）和冷加压试验（CPT）反应。BAFMD 和 CPT 的绝对（mm）反应组合产生血管操作范围（VOR）。
CON 组的基线 BAFMD 较高（CHF：2.98±1.49%；CON：6.21±1.21%；p=0.01），而 CHF 组的 CPT 反应较高（CHF：3.38±0.83%；CON：2.46±0.62%；p=0.05）。CON 组的基线 VOR 倾向于更大（CHF：0.28±0.05mm；CON：0.32±0.12mm；p=0.06）。训练增加了握力（~5%；两组均 p<0.05），BAFMD（CHF：2.98±1.49%至 3.75±1.56%；CON：6.21±1.21%至 8.02±1.75%；p=0.01）和 VOR（CHF：0.28±0.05mm 至 0.3±0.09mm；CON：0.32±0.12mm 至 0.42±0.11mm；p=0.01）。CPT 反应无显著变化。所有标志物在脱训后均接近训练前值。
握力运动增加了 CHF 和 CON 受试者的力量、BAFMD 和 VOR。这些改善是短暂的，在训练刺激去除后恢复到训练前值。
