Department of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, No.12, Wulumuqi Middle Road, Shanghai 200040, China.
Nutr Metab Cardiovasc Dis. 2013 Oct;23(10):973-9. doi: 10.1016/j.numecd.2012.08.001. Epub 2012 Sep 23.
Low high-density lipoprotein cholesterol (HDL-c) is a risk factor for cardiovascular disease. Brachial-ankle pulse wave velocity (baPWV) is an indicator of arterial stiffness, which is recognized as a predictor of cardiovascular disease. The aim of this study was to investigate the association between HDL-c and baPWV among middle-aged and elderly Chinese.
A total number of 1133 Chinese (430 men, 703 women) aged from 50 to 90 years old were recruited from Shanghai downtown district. The baPWV and major cardiovascular risk factors of the participants were measured.
Serum HDL-c was negatively correlated with baPWV (r = -0.143, P < 0.001) after adjustment for age and gender. Multivariate linear regression analysis demonstrated that age (P < 0.001), systolic blood pressure (P < 0.001), HDL-c (P < 0.001), smoking (P = 0.001), BMI (P = 0.002), fasting plasma glucose (P = 0.004), and white blood cell (P = 0.005) were independently associated with baPWV. After multiple adjustments, participants in the highest quartile of HDL-c had an odds ratio of 0.442 (95% CI 0.268-0.729) for developing high arterial stiffness compared with participants in the lowest quartile. The association remained significant after further adjustment for major cardiovascular risk factors.
HDL-c has an independent protective effect on arterial stiffness in middle-aged and elderly Chinese. Early detection of HDL-c level is important in high risk populations with arterial stiffness. Increasing HDL-c level may be an attractive therapeutic target for the prevention of arterial function and subsequent disease.
低高密度脂蛋白胆固醇（HDL-c）是心血管疾病的危险因素。肱踝脉搏波速度（baPWV）是动脉僵硬度的指标，被认为是心血管疾病的预测指标。本研究旨在探讨中年和老年中国人中 HDL-c 与 baPWV 之间的关系。
共招募了 1133 名年龄在 50 至 90 岁之间的中国上海市区居民（430 名男性，703 名女性）。测量了参与者的 baPWV 和主要心血管危险因素。
调整年龄和性别后，血清 HDL-c 与 baPWV 呈负相关（r = -0.143，P <0.001）。多元线性回归分析表明，年龄（P <0.001）、收缩压（P <0.001）、HDL-c（P <0.001）、吸烟（P = 0.001）、BMI（P = 0.002）、空腹血糖（P = 0.004）和白细胞（P = 0.005）与 baPWV 独立相关。经过多次调整后，HDL-c 最高四分位的参与者发生高动脉僵硬度的比值比为 0.442（95%CI 0.268-0.729），而 HDL-c 最低四分位的参与者为 1。进一步调整主要心血管危险因素后，该关联仍然显著。
HDL-c 对中年和老年中国人的动脉僵硬度具有独立的保护作用。在存在动脉僵硬的高危人群中，早期检测 HDL-c 水平很重要。增加 HDL-c 水平可能是预防动脉功能和随后疾病的有吸引力的治疗靶点。
