甘油三酯与高密度脂蛋白胆固醇（HDL-C）比值与日本人群动脉僵硬度的关系：基于横断面研究的二次分析。
Triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio and arterial stiffness in Japanese population: a secondary analysis based on a cross-sectional study.
机构信息
Department of Immunology and Microbiology, Guiyang College of Traditional Chinese Medicine, 84# ShiDong Road, Guiyang, 550001, Guizhou, China.
School of forensic medicine, Guizhou Medical University, 2# Beijing Road, Guiyang, 550001, Guizhou, China.
出版信息
Lipids Health Dis. 2018 May 29;17(1):130. doi: 10.1186/s12944-018-0776-7.
BACKGROUND
Previous studies have revealed that triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio (henceforth TG/HDL-C) is one of major risk factors of cardiovascular diseases, insulin resistance and metabolism syndrome. However, there are fewer scientific dissertations about the correlation between TG/HDL-C and bapWV. This study was undertaken to investigate the relationship between Triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio and brachial-ankle pulse wave velocity (baPWV) in Japanese.
METHODS
The present study was a cross-sectional study. 912 Japanese men and women, aging 24-84 years old, received a health medical a health check-up program including the results from baPWV inspection and various standardized questionnaire in a health examination Center in Japan. Main outcome measures included TG/HDL-C ratio, baPWV, fatty liver, postmenopausal status. Abdominal ultrasonography was used to diagnose fatty liver. Postmenopausal state was defined as beginning 1 year after the cessation of menses. It was noted that the entire study was completed by Fukuda et al., and uploaded the data to the DATADRYAD website. The author only used this data for secondary analysis.
RESULTS
After adjusting potential confounders (age, sex, BMI, SBP, DBP, AST, ALT, GGT, uric acid, fasting glucose, TC, LDL, eGFR, smoking and exercise status, fatty liver, alcohol consumption and ABI), non-linear relationship was detected between TG/HDL-C and baPWV, whose point was 5.6. The effect sizes and the confidence intervals on the left and right sides of inflection point were 12.7 (1.9 to 23.5) and - 16.7 (- 36.8 to 3.3), respectively. Subgroup analysis showed, in participants with excessive alcohol consumption (more than 280 g/week), that TG/HDL-C had a negative correlation with BAPWV (β = - 30.7, 95%CI (- 53.1, - 8.4)), and the P for interaction was less than 0.05, CONCLUSION: The relationship between TG/HDL-C and baPWV is non-linear. TG/HDL-C was positively related with baPWV when TG/HDL-C is less than 5.6. In addition, while the trend is opposite in excessive alcoholic subjects.
背景
先前的研究表明，甘油三酯与高密度脂蛋白胆固醇（HDL-C）的比值（以下简称 TG/HDL-C）是心血管疾病、胰岛素抵抗和代谢综合征的主要危险因素之一。然而，关于 TG/HDL-C 与 bapWV 之间的相关性，科学论文较少。本研究旨在探讨日本人 TG/HDL-C 与肱踝脉搏波速度（baPWV）之间的关系。
方法
本研究为横断面研究。912 名年龄在 24-84 岁的日本男女接受了健康体检计划，包括 baPWV 检查结果和各种标准化问卷。主要观察指标包括 TG/HDL-C 比值、baPWV、脂肪肝、绝经后状态。腹部超声用于诊断脂肪肝。绝经后状态定义为绝经后 1 年。本研究由 Fukuda 等人完成，并将数据上传至 DATADRYAD 网站。作者仅使用此数据进行二次分析。
结果
在调整了潜在混杂因素（年龄、性别、BMI、SBP、DBP、AST、ALT、GGT、尿酸、空腹血糖、TC、LDL、eGFR、吸烟和运动状况、脂肪肝、饮酒和 ABI）后，TG/HDL-C 与 baPWV 之间存在非线性关系，拐点为 5.6。拐点左侧和右侧的效应大小和置信区间分别为 12.7（1.9 至 23.5）和-16.7（-36.8 至 3.3）。亚组分析显示，在过量饮酒（每周超过 280 克）的参与者中，TG/HDL-C 与 BAPWV 呈负相关（β=-30.7，95%CI（-53.1，-8.4）），交互作用的 P 值小于 0.05。
结论
TG/HDL-C 与 baPWV 之间的关系是非线性的。当 TG/HDL-C 小于 5.6 时，TG/HDL-C 与 baPWV 呈正相关。此外，在过量饮酒的受试者中，趋势相反。
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