住院成人中艰难梭菌阴性腹泻时行不必要的重复艰难梭菌 PCR 检测。
Unnecessary repeat Clostridium difficile PCR testing in hospitalized adults with C. difficile-negative diarrhea.
机构信息
Infectious Disease Division and Clinical Microbiology Laboratory, Winthrop-University Hospital, Mineola, NY 11501, USA.
出版信息
Eur J Clin Microbiol Infect Dis. 2013 Jan;32(1):97-9. doi: 10.1007/s10096-012-1719-2. Epub 2012 Aug 15.
The aim of this study was to determine the extent and associated costs of repeat Clostridium difficile stool polymerase chain reaction (PCR) assays in patients with initially negative PCRs. C. difficile stool PCRs were done on adult hospitalized patients with diarrhea. The number/time course of repeat PCRs on initially negative PCR patients was determined. Of 5,027 C. difficile stool PCRs, 814 (16.2 %) were positive and 4,213 (83.8 %) were negative. Ninety-seven of the initially PCR-negative patients had >2 repeat tests 1-59 days after the initial negative stool PCR. Repeat negative PCR testing rarely resulted in a subsequent positive result (0.05 %). The unnecessary costs of 97 repeat PCRs was $32,658.00. Many of these patients were originally given empiric oral anti-C. difficile therapy, in spite of repeatedly negative PCRs.
这项研究的目的是确定初始 PCR 阴性的患者重复进行艰难梭菌粪便聚合酶链反应（PCR）检测的程度和相关费用。对患有腹泻的住院成年患者进行艰难梭菌粪便 PCR。确定了初始 PCR 阴性患者重复 PCR 的次数/时间进程。在 5027 例艰难梭菌粪便 PCR 中，814 例（16.2%）为阳性，4213 例（83.8%）为阴性。97 例初始 PCR 阴性患者在初始阴性粪便 PCR 后 1-59 天进行了>2 次重复检测。重复的阴性 PCR 检测很少导致后续的阳性结果（0.05%）。97 次重复 PCR 的不必要费用为 32658.00 美元。尽管重复的 PCR 检测为阴性，但许多此类患者最初还是接受了经验性口服抗艰难梭菌治疗。
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