Csako G A, Cetnarowski-Cropp A B, Pucino F
Department of Clinical Pathology, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892.
DICP. 1990 Jan;24(1):26-7. doi: 10.1177/106002809002400105.
Various brands of over-the counter (OTC) exogenous thyroid hormones are available in health food stores and retail pharmacies. Two commercially available OTC thyroid products were analyzed for total thyroxine (T4) and triiodothyronine (T3) content. The strength of a liquid thyroid gland extract was unlabeled and that of the solid oral preparation was 45 mg per table. The T4 concentration of the liquid preparation was less than 10 micrograms/dL; that of T3 was below the analytical sensitivity of our assay (less than 15 ng/dL). Tablet content of T4 and of T3 was up to 0.5 micrograms and up to 50 ng, respectively. Preliminary data on these OTC thyroid gland extracts cannot be extrapolated to all OTC thyroid products, but they suggest that such products generally contain concentrations of T4 and T3 below clinical effectiveness. Further analytical study is warranted.
各种品牌的非处方（OTC）外源性甲状腺激素在保健食品商店和零售药店均有销售。对两种市售的非处方甲状腺产品进行了总甲状腺素（T4）和三碘甲状腺原氨酸（T3）含量分析。一种液体甲状腺提取物的浓度未标明，固体口服制剂的浓度为每片45毫克。液体制剂的T4浓度低于10微克/分升；T3浓度低于我们检测方法的分析灵敏度（低于15纳克/分升）。片剂中T4和T3的含量分别高达0.5微克和50纳克。这些非处方甲状腺提取物的初步数据不能外推至所有非处方甲状腺产品，但表明此类产品中T4和T3的浓度通常低于临床有效浓度。有必要进行进一步的分析研究。
