Handa K, Sasaki J, Saku K, Kono S, Arakawa K
Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
Am J Cardiol. 1990 Feb 1;65(5):287-9. doi: 10.1016/0002-9149(90)90289-d.
The relation of alcohol consumption to serum lipids and the severity of coronary atherosclerosis was examined in 212 men undergoing coronary angiography. The severity of coronary atherosclerosis was assessed in terms of the presence of greater than or equal to 75% diameter stenosis and the Gensini severity score. Alcohol consumption was divided into 4 categories: none (0 ml alcohol/week), light (1 to 100 ml alcohol/week), moderate (101 to 300 ml alcohol/week) and heavy (greater than or equal to 301 ml alcohol/week). Alcohol consumption was positively related to high-density lipoprotein cholesterol and inversely related to total cholesterol, but was not associated with triglyceride. After adjustment for these serum lipids as well as for cigarette smoking and systemic hypertension, the risk of coronary stenosis was significantly decreased in the moderate drinkers. A decreased risk among moderate drinkers also was noted in terms of Gensini's severity score. These findings suggest that moderate alcohol consumption may protect against severe coronary atherosclerosis.
对212名接受冠状动脉造影的男性，研究了饮酒量与血脂及冠状动脉粥样硬化严重程度之间的关系。根据直径狭窄大于或等于75%的情况以及Gensini严重程度评分来评估冠状动脉粥样硬化的严重程度。饮酒量分为4类：不饮酒（每周饮酒0毫升）、少量饮酒（每周饮酒1至100毫升）、适度饮酒（每周饮酒101至300毫升）和大量饮酒（每周饮酒大于或等于301毫升）。饮酒量与高密度脂蛋白胆固醇呈正相关，与总胆固醇呈负相关，但与甘油三酯无关。在对这些血脂以及吸烟和系统性高血压进行校正后，适度饮酒者冠状动脉狭窄的风险显著降低。就Gensini严重程度评分而言，适度饮酒者的风险也有所降低。这些发现表明，适度饮酒可能预防严重的冠状动脉粥样硬化。
