Yamaguchi Koji, Sata Masataka
Department of Cardiovascular Medicine, Tokushima University Hospital.
Nihon Rinsho. 2012 Sep;70(9):1571-6.
Many kinds of antihypertensive drugs have been used recently. JSH2009 supported that we should prescribe one of these drugs [calcium channel blockers, angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, diuretics and beta-adrenergic blockers] for hypertensive patients at first. In this review, we provide a brief overview of the ARBs and ACE inhibitors and discuss the clinical evidence related to the use of ACE inhibitors and ARBs. In accordance with JSH2009, we summarize the clinical backgrounds which we should use ARB or ACE inhibitors for hypertensive patients with: left ventricular hypertrophy, heart failure, atrial fibrillation, old myocardial infarction, protein urea, renal disturbance, chronic cerebral stroke, diabetes mellitus, metabolic syndromes and the elderly.
近年来，多种抗高血压药物已被广泛应用。日本高血压学会2009年版指南支持，对于高血压患者，应首选以下药物之一进行治疗[钙通道阻滞剂、血管紧张素受体阻滞剂（ARB）、血管紧张素转换酶（ACE）抑制剂、利尿剂和β-肾上腺素能阻滞剂]。在本综述中，我们简要概述了ARB和ACE抑制剂，并讨论了与ACE抑制剂和ARB使用相关的临床证据。根据日本高血压学会2009年版指南，我们总结了在以下高血压患者中应使用ARB或ACE抑制剂的临床背景：左心室肥厚、心力衰竭、心房颤动、陈旧性心肌梗死、蛋白尿、肾功能障碍、慢性脑卒、糖尿病、代谢综合征以及老年患者。
