Fraunhofer MEVIS, Bremen, 28359 Bremen, Germany.
IEEE Trans Med Imaging. 2013 Feb;32(2):210-22. doi: 10.1109/TMI.2012.2219881. Epub 2012 Sep 20.
Segmentation of the pulmonary lobes is relevant in clinical practice and particularly challenging for cases with severe diseases or incomplete fissures. In this work, an automated segmentation approach is presented that performs a marker-based watershed transformation on computed tomography (CT) scans to subdivide the lungs into lobes. A cost image for the watershed transformation is computed by combining information from fissures, bronchi, and pulmonary vessels. The lobar markers are calculated by an analysis of the automatically labeled bronchial tree. By integration of information from several anatomical structures the segmentation is made robust against incomplete fissures. For evaluation the method was compared to a recently published method on 20 CT scans with no or mild disease. The average distances to the reference segmentation were 0.69, 0.67, and 1.21 mm for the left major, right major, and right minor fissure, respectively. In addition the results were submitted to LOLA11, an international lung lobe segmentation challenge with publically available data including cases with severe diseases. The average distances to the reference for the 55 CT scans provided by LOLA11 were 0.98, 3.97, and 3.09 mm for the left major, right major, and right minor fissure. Moreover, an analysis of the relation between segmentation quality and fissure completeness showed that the method is robust against incomplete fissures.
肺叶分割在临床实践中很重要,对于严重疾病或不完整裂的病例尤其具有挑战性。在这项工作中,提出了一种自动分割方法,该方法对计算机断层扫描(CT)图像进行基于标记的分水岭变换,将肺部细分为叶。分水岭变换的代价图像是通过组合裂、支气管和肺血管的信息计算得到的。叶标记是通过对自动标记的支气管树进行分析计算得到的。通过整合来自多个解剖结构的信息,分割对不完整的裂具有鲁棒性。为了进行评估,该方法与最近发表的一种方法在 20 个无或轻度疾病的 CT 扫描上进行了比较。对于左主裂、右主裂和右小裂,平均距离分别为 0.69、0.67 和 1.21 毫米。此外,结果提交给 LOLA11,这是一个国际肺叶分割挑战,提供了公开数据,包括严重疾病的病例。对于 LOLA11 提供的 55 个 CT 扫描,左主裂、右主裂和右小裂的平均距离分别为 0.98、3.97 和 3.09 毫米。此外,对分割质量与裂完整性之间关系的分析表明,该方法对不完整的裂具有鲁棒性。