Smith M H, Denninghoff K R, Hillman L W, Chipman R A
J Biomed Opt. 1998 Jul;3(3):296-303. doi: 10.1117/1.429856.
We describe a noninvasive technique and instrumentation for measuring the oxygen saturation of blood in retinal arteries and veins. The measurements are made by shining low-power lasers into the eye, and scanning the beams across a retinal blood vessel. The light reflected and scattered back out of the eye is collected and measured. The oxygen saturation of blood within the vessel is determined by analyzing the vessel absorption profiles at two wavelengths. A complete saturation measurement can be made in less than 1 s, allowing real-time measurement during physiologic changes. The sensitivity of this measurement technique to changes in retinal saturation has been demonstrated through a series of pilot studies in anesthetized swine. We present data indicating that retinal venous oxygen saturation decreases during ongoing blood loss, demonstrating a potential application of an eye oximeter to noninvasively monitor blood loss. © 1998 Society of Photo-Optical Instrumentation Engineers.
我们描述了一种用于测量视网膜动脉和静脉血氧饱和度的非侵入性技术及仪器。通过向眼睛发射低功率激光并使光束扫过视网膜血管来进行测量。收集并测量从眼睛反射和散射回来的光。通过分析血管在两个波长处的吸收谱来确定血管内血液的氧饱和度。一次完整的饱和度测量可在不到1秒内完成，从而能够在生理变化过程中进行实时测量。通过在麻醉猪身上进行的一系列初步研究，已证明了这种测量技术对视网膜饱和度变化的敏感性。我们给出的数据表明，在持续失血过程中视网膜静脉血氧饱和度会降低，这证明了眼血氧计在无创监测失血方面的潜在应用。© 1998美国光电仪器工程师协会
