Engstrom R E, Holland G N, Hardy W D, Meiselman H J
Jules Stein Eye Institute, UCLA Medical Center 90024-1771.
Am J Ophthalmol. 1990 Feb 15;109(2):153-61. doi: 10.1016/s0002-9394(14)75980-x.
The severity of conjunctival microvascular changes and the presence of cotton-wool spots were compared to factors that may affect blood flow (hematocrit level, red cell aggregation, fibrinogen level, plasma viscosity, circulating immune complexes, and quantitative immunoglobulin levels) in 22 human immunodeficiency virus-infected individuals. The severity of conjunctival disease was associated with increased zeta sedimentation ratios (a measure of red cell aggregation) and fibrinogen levels. The presence of cotton-wool spots was also associated with higher fibrinogen levels. Plasma viscosity and quantitative IgG levels were above normal levels in most patients, although a relationship to disease severity was not established. Altered blood flow may contribute to vascular damage and ocular ischemic lesions in patients with human immunodeficiency virus infection.
在22名人类免疫缺陷病毒感染个体中，将结膜微血管变化的严重程度和棉絮斑的存在情况与可能影响血流的因素（血细胞比容水平、红细胞聚集、纤维蛋白原水平、血浆粘度、循环免疫复合物和定量免疫球蛋白水平）进行了比较。结膜疾病的严重程度与ζ沉降率（红细胞聚集的一种测量指标）和纤维蛋白原水平升高有关。棉絮斑的存在也与较高的纤维蛋白原水平有关。大多数患者的血浆粘度和定量IgG水平高于正常水平，尽管未确立与疾病严重程度的关系。血流改变可能导致人类免疫缺陷病毒感染患者的血管损伤和眼部缺血性病变。
