Gupta V K
University of Maryland Baltimore County, Baltimore, Maryland 21250, USA.
Eur Phys J E Soft Matter. 2012 Sep;35(9):94. doi: 10.1140/epje/i2012-12094-9. Epub 2012 Sep 27.
Monte Carlo simulation of the rupture of multiple receptor-ligand bonds between two PMN cells suspended in a Newtonian fluid is performed. In the presence of a hydrodynamic drag force acting on two PMN cells the interplay of multiple receptor-ligand bonds between these cells leads to a bimodal distribution of the bond rupture force at certain loading rates. Specifically, it is found that the interplay of multiple bonds between two PMN cells in the presence of hydrodynamic drag force acting on these cells modifies the bond energy landscape in such a way as to lead to a bimodal distribution of the bond rupture force where a low force peak switches to a high force peak as the loading rate is increased progressively, characteristics of two-state systems.
对悬浮在牛顿流体中的两个中性粒细胞之间多个受体-配体键的断裂进行了蒙特卡罗模拟。在作用于两个中性粒细胞的流体动力阻力存在的情况下，这些细胞之间多个受体-配体键的相互作用导致在特定加载速率下键断裂力的双峰分布。具体而言，发现在作用于这些细胞的流体动力阻力存在的情况下，两个中性粒细胞之间多个键的相互作用以这样一种方式改变了键能景观，即导致键断裂力的双峰分布，其中随着加载速率逐渐增加，低力峰转变为高力峰，这是双态系统的特征。
