与手指采血OraQuick ADVANCE快速HIV 1/2抗体检测假阳性结果相关的因素。
Factors associated with false-positive results from fingerstick OraQuick ADVANCE rapid HIV 1/2 antibody test.
作者信息
Rifkin Samara B, Owens Lauren E, Greenwald Jeffrey L
机构信息
1Boston University School of Medicine, Boston, MA, USA.
出版信息
J Int Assoc Physicians AIDS Care (Chic). 2012 Nov-Dec;11(6):356-60. doi: 10.1177/1545109712454194. Epub 2012 Sep 26.
OBJECTIVE
Identify factors associated with false-positive rapid HIV antibody tests.
DESIGN
This retrospective cohort study with nested case-controls involved patients tested for HIV by Boston Medical Center (BMC) affiliates.
METHODS
Cases had a reactive fingerstick OraQuick ADVANCE rapid HIV 1/2 antibody test and a negative Western blot. Controls had nonreactive rapid tests. We compared the prevalence of HIV risk factors between cases and the total nonreactive population and the prevalence of other clinical factors between cases and controls.
RESULTS
Of the 15 094 tests, 14 937 (98.9%) were negative and 11 (0.07%) were false positives (specificity of 99.9%). Cases were more likely to have had an HIV-infected sex partner and to be tested at certain sites compared to true negatives. More cases than controls had O-negative blood type.
CONCLUSION
O-negative blood type and sex with an HIV-infected person may increase false-positive HIV fingerstick results. More targeted studies should examine these risk factors.
目的
确定与HIV抗体快速检测假阳性相关的因素。
设计
这项嵌套病例对照的回顾性队列研究涉及由波士顿医疗中心（BMC）附属机构进行HIV检测的患者。
方法
病例组的手指采血OraQuick ADVANCE快速HIV 1/2抗体检测呈阳性，而免疫印迹法检测呈阴性。对照组的快速检测无反应。我们比较了病例组与总的无反应人群之间HIV危险因素的患病率，以及病例组与对照组之间其他临床因素的患病率。
结果
在15094次检测中，14937次（98.9%）为阴性，11次（0.07%）为假阳性（特异性为99.9%）。与真阴性相比，病例组更有可能有感染HIV的性伴侣，并且在某些地点接受检测。病例组中O型阴性血的人数多于对照组。
结论
O型阴性血以及与感染HIV的人发生性行为可能会增加HIV手指采血检测结果假阳性的几率。更多有针对性的研究应考察这些危险因素。
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