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Methods Mol Biol. 2012;921:41-50. doi: 10.1007/978-1-62703-005-2_7.
2
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[The type IV secretion system encoded by the cag PAI of Helicobacter pylori].[幽门螺杆菌cag致病岛编码的IV型分泌系统]
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本文引用的文献

1
Peptidoglycan deacetylation in Helicobacter pylori contributes to bacterial survival by mitigating host immune responses.幽门螺杆菌中肽聚糖脱乙酰化通过减轻宿主免疫应答促进细菌存活。
Infect Immun. 2010 Nov;78(11):4660-6. doi: 10.1128/IAI.00307-10. Epub 2010 Aug 30.
2
NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.NOD1 通过诱导 I 型 IFN 和激活 ISGF3 信号通路促进小鼠宿主抵抗幽门螺杆菌。
J Clin Invest. 2010 May;120(5):1645-62. doi: 10.1172/JCI39481. Epub 2010 Apr 12.
3
Helicobacter pylori induces MAPK phosphorylation and AP-1 activation via a NOD1-dependent mechanism.幽门螺杆菌通过 NOD1 依赖性机制诱导 MAPK 磷酸化和 AP-1 激活。
J Immunol. 2009 Dec 15;183(12):8099-109. doi: 10.4049/jimmunol.0900664.
4
Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner.幽门螺杆菌 IV 型分泌装置以一种新型的非 RGDI 依赖性方式利用β1 整合素。
PLoS Pathog. 2009 Dec;5(12):e1000684. doi: 10.1371/journal.ppat.1000684. Epub 2009 Dec 4.
5
Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.幽门螺杆菌 CagA 通过模拟宿主底物来抑制 PAR1-MARK 家族激酶。
Nat Struct Mol Biol. 2010 Jan;17(1):130-2. doi: 10.1038/nsmb.1705. Epub 2009 Dec 6.
6
Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells.细菌膜泡将肽聚糖递呈给上皮细胞中的 NOD1。
Cell Microbiol. 2010 Mar;12(3):372-85. doi: 10.1111/j.1462-5822.2009.01404.x. Epub 2009 Nov 2.
7
Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.幽门螺杆菌 CagA 通过靶向 TAK1 进行 TRAF6 介导的 Lys63 泛素化来激活 NF-κB。
EMBO Rep. 2009 Nov;10(11):1242-9. doi: 10.1038/embor.2009.210. Epub 2009 Oct 9.
8
Role of partitioning-defective 1/microtubule affinity-regulating kinases in the morphogenetic activity of Helicobacter pylori CagA.分选缺陷蛋白1/微管亲和调节激酶在幽门螺杆菌CagA形态发生活性中的作用
J Biol Chem. 2009 Aug 21;284(34):23024-36. doi: 10.1074/jbc.M109.001008. Epub 2009 Jun 24.
9
Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability.幽门螺杆菌细胞毒素相关基因A(CagA)会导致有丝分裂损伤并诱发染色体不稳定。
J Biol Chem. 2009 Aug 14;284(33):22166-22172. doi: 10.1074/jbc.M109.035766. Epub 2009 Jun 22.
10
Delineation of a carcinogenic Helicobacter pylori proteome.明确致癌性幽门螺杆菌蛋白质组。
Mol Cell Proteomics. 2009 Aug;8(8):1947-58. doi: 10.1074/mcp.M900139-MCP200. Epub 2009 May 25.

幽门螺杆菌细胞毒素相关基因致病岛

The Helicobacter pylori cag Pathogenicity Island.

作者信息

Noto Jennifer M, Peek Richard M

机构信息

Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, MRB IV 1030C MRB IV, Nashville, TN, USA.

出版信息

Methods Mol Biol. 2012;921:41-50. doi: 10.1007/978-1-62703-005-2_7.

DOI:10.1007/978-1-62703-005-2_7
PMID:23015490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3547679/
Abstract

The cag pathogenicity island is a well-characterized virulence determinant. It is composed of 32 genes that encode a type IV bacterial secretion system and is linked with a more severe clinical outcome. The following chapters will explore the manipulation of bacterial factors in order to understand their role in gastric mucosal disease.

摘要

cag致病岛是一种特征明确的毒力决定因素。它由32个基因组成,这些基因编码一种IV型细菌分泌系统,并且与更严重的临床结果相关。以下各章将探讨对细菌因素的操控,以便了解它们在胃黏膜疾病中的作用。