Department of Biological Sciences, College of Science, University of Santo Tomas, Manila, Philippines.
Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines.
Asian Pac J Cancer Prev. 2024 Oct 1;25(10):3363-3370. doi: 10.31557/APJCP.2024.25.10.3363.
Helicobacter pylori infections have been suggested to be associated with several extra gastric maladies, including hepatobiliary cancer (HBC). However, reports on the relationship between H. pylori infection and HBC showed variable and contrasting findings. This study aimed to address these contrasting findings and clarify the effect of H. pylori infections on HBC. Thus, we performed a systematic literature review of published related studies and a meta-analysis of eight eligible publications.
Related studies were searched in various database websites namely PubMed, ScienceDirect, Google Scholar, and Cochrane Library. Eligible studies were collated, and data were extracted. The odds ratio (OR) and 95% confidence interval (CI) were computed and interpreted using Review Manager 5.4.
Our overall analysis showed a significant association between H. pylori infection and HBC risk. Post-outlier analysis revealed homogeneous data (I2 = 0%, p = 0.82) and significant association (OR: 2.63, 95% CI: 1.62-4.28, P < 0.0001). Subgroup analysis based on the method of diagnosis (PCR OR: 2.46, 95% CI: 1.37-4.42, P = 0.003; ELISA OR: 2.40, 95% CI = 0.99 - 5.85, P = 0.05) showed almost similar associations and odds ratios, but only the PCR group (I2 = 0%, P = 0.72) showed homogeneity. Subgroup analysis based on specimen types revealed consistent results for liver tissue (I2 = 0%, P = 0.82) and bile (I2= 0%, P = 0.76) samples, showing low heterogeneity. In contrast, serum samples (OR: 2.40, 95% CI = 0.99 - 5.85, P = 0.05) displayed a potential but statistically nonsignificant association, while bile samples demonstrated a significant association (OR: 3.65, 95% CI: 1.56-8.52, P = 0.003).
Overall, the present study suggests that H. pylori infection is associated with increased susceptibility to HBC development, with an increased effect found in bile and serum samples as specimens of choice for diagnosing H. pylori.
幽门螺杆菌感染与多种胃部以外的疾病有关，包括肝胆癌（HBC）。然而，关于 H. pylori 感染与 HBC 之间关系的报告显示结果存在差异和矛盾。本研究旨在解决这些矛盾的发现并阐明 H. pylori 感染对 HBC 的影响。因此，我们对已发表的相关研究进行了系统的文献回顾和八项合格出版物的荟萃分析。
在各种数据库网站（即 PubMed、ScienceDirect、Google Scholar 和 Cochrane Library）中搜索相关研究。对合格的研究进行整理和提取数据。使用 Review Manager 5.4 计算并解释比值比（OR）和 95%置信区间（CI）。
我们的总体分析表明，H. pylori 感染与 HBC 风险之间存在显著关联。剔除异常值后分析显示数据具有同质性（I2=0%，p=0.82）且存在显著关联（OR：2.63，95%CI：1.62-4.28，P<0.0001）。基于诊断方法的亚组分析（PCR-OR：2.46，95%CI：1.37-4.42，P=0.003；ELISA-OR：2.40，95%CI=0.99-5.85，P=0.05）显示出几乎相似的关联和优势比，但只有 PCR 组（I2=0%，P=0.72）显示出同质性。基于标本类型的亚组分析显示，肝组织（I2=0%，P=0.82）和胆汁（I2=0%，P=0.76）标本的结果一致，异质性较低。相反，血清标本（OR：2.40，95%CI=0.99-5.85，P=0.05）显示出潜在但统计学上无显著性的关联，而胆汁标本则显示出显著的关联（OR：3.65，95%CI：1.56-8.52，P=0.003）。
总体而言，本研究表明 H. pylori 感染与 HBC 发展的易感性增加有关，在选择用于诊断 H. pylori 的胆汁和血清标本中发现作用增强。
