Veronese Piero, Dodi Icilio
Pediatric Infectious Disease Unit, Barilla Children's Hospital of Parma, 43126 Parma, Italy.
Microorganisms. 2024 Dec 23;12(12):2669. doi: 10.3390/microorganisms12122669.
Campylobacteriosis is a leading cause of infectious diarrhea and foodborne illness worldwide. infection is primarily transmitted through the consumption of contaminated food, especially uncooked meat, or untreated water; contact with infected animals or contaminated environments; poultry is the primary reservoir and source of human transmission. The clinical spectrum of / infection can be classified into two distinct categories: gastrointestinal and extraintestinal manifestations. Late complications are reactive arthritis, Guillain-Barré syndrome, and Miller Fisher syndrome. In the pediatric population, the 0-4 age group has the highest incidence of campylobacteriosis. Regarding the use of specific antimicrobial therapy, international guidelines agree in recommending it for severe intestinal infections. Host factors, including malnutrition, immunodeficiency, and malignancy, can also influence the decision to treat. The Centers for Disease Control and Prevention (CDC) has identified antibiotic resistance in as a 'significant public health threat' due to increasing resistance to FQs or macrolides. Although numerous vaccines have been proposed in recent years to reduce the intestinal colonization of poultry, none have shown sufficient efficacy to provide a definitive solution.
弯曲杆菌病是全球感染性腹泻和食源性疾病的主要病因。感染主要通过食用受污染的食物传播，尤其是未煮熟的肉类或未经处理的水；接触受感染的动物或受污染的环境；家禽是人类传播的主要宿主和来源。感染的临床症状可分为两大类：胃肠道表现和肠外表现。晚期并发症有反应性关节炎、吉兰 - 巴雷综合征和米勒 - 费雪综合征。在儿童群体中，0至4岁年龄组弯曲杆菌病的发病率最高。关于使用特定的抗菌治疗，国际指南一致建议对严重肠道感染使用。宿主因素，包括营养不良、免疫缺陷和恶性肿瘤，也会影响治疗决策。美国疾病控制与预防中心（CDC）已将弯曲杆菌的抗生素耐药性确定为“重大公共卫生威胁”，因为对氟喹诺酮类药物或大环内酯类药物的耐药性不断增加。尽管近年来已提出多种疫苗以减少家禽肠道定植，但尚无一种显示出足够的疗效来提供最终解决方案。
