Wang Cheng, Gao Yanhui, Wang Wei, Zhao Lijun, Zhang Wei, Han Hepeng, Shi Yuxia, Yu Guangqian, Sun Dianjun
Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University; Key Lab of Etiology and Epidemiology, Education Bureau of Hei Long Jiang Province & Ministry of Health (23618104), Harbin 150081, China.
BMJ Open. 2012 Sep 25;2(5). doi: 10.1136/bmjopen-2012-001564. Print 2012.
To assess the effects of provided fluoride-safe drinking-water for the prevention and control of endemic fluorosis in China.
A national cross-sectional study in China.
In 1985, randomly selected villages in 27 provinces (or cities and municipalities) in 5 geographic areas all over China.
Involved 81 786 children aged from 8 to 12 and 594 698 adults aged over 16.
The prevalence of dental fluorosis and clinical skeletal fluorosis, the fluoride concentrations in the drinking-water in study villages and in the urine of subjects.
The study showed that in the villages where the drinking-water fluoride concentrations were higher than the government standard of 1.2 mg/l, but no fluoride-safe drinking-water supply scheme was provided (FNB areas), the prevalence rate and index of dental fluorosis in children, and prevalence rate of clinical skeletal fluorosis in adults were all significantly higher than those in the historical endemic fluorosis villages after the fluoride-safe drinking-water were provided (FSB areas). Additionally, the prevalence rate of dental fluorosis as well as clinical skeletal fluorosis, and the concentration of fluoride in urine were found increased with the increase of fluoride concentration in drinking-water, with significant positive correlations in the FNB areas. While, the prevalence rate of dental fluorosis and clinical skeletal fluorosis in different age groups and their degrees of prevalence were significantly lower in the FSB areas than those in the FNB areas.
The provision of fluoride-safe drinking-water supply schemes had significant effects on the prevention and control of dental fluorosis and skeletal fluorosis. The study also indicated that the dental and skeletal fluorosis is still prevailing in the high-fluoride drinking-water areas in China.
评估提供氟安全饮用水对中国地方性氟中毒防治的效果。
中国的一项全国性横断面研究。
1985年，在中国5个地理区域的27个省（或直辖市）随机选取村庄。
涉及81786名8至12岁儿童和594698名16岁以上成年人。
氟斑牙和临床骨氟中毒的患病率、研究村庄饮用水中的氟化物浓度以及受试者尿液中的氟化物浓度。
研究表明，在饮用水氟化物浓度高于政府规定的1.2毫克/升标准但未提供氟安全饮用水供应方案的村庄（FNB地区），儿童氟斑牙的患病率和指数以及成年人临床骨氟中毒的患病率均显著高于提供氟安全饮用水后的历史地方性氟中毒村庄（FSB地区）。此外，在FNB地区，氟斑牙以及临床骨氟中毒的患病率和尿液中的氟化物浓度随饮用水中氟化物浓度的增加而升高，呈显著正相关。而在FSB地区，不同年龄组的氟斑牙和临床骨氟中毒患病率及其患病程度均显著低于FNB地区。
提供氟安全饮用水供应方案对氟斑牙和骨氟中毒的防治有显著效果。该研究还表明，中国高氟饮用水地区的氟斑牙和骨氟中毒仍然普遍存在。
