Martini Clinic, Prostate Cancer Centre, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Oncologist. 2012;17 Suppl 1(Suppl 1):4-8. doi: 10.1634/theoncologist.2012-S1-04.
Prostate cancer affects a high proportion of men over 70 years of age, who are likely to have high-risk disease and a substantial risk of prostate-cancer-specific death. With life expectancy increasing worldwide, the burden of prostate cancer is also expected to rise. Thus, effective management of this high-risk senior patient group is increasingly important. Radical prostatectomy can increase survival and decrease the risk of metastatic progression. Postsurgery complications are affected more by comorbidity than by age. In patients without comorbidities, surgery is associated with a low risk of mortality. Advanced age may increase the likelihood of incontinence following radical prostatectomy, but patients with higher risk disease are no more likely to experience this complication compared with lower risk groups. Treatment decisions should be made after considering the health status and life expectancy of the individual patient. If eligible, the patient should be offered radical prostatectomy as a potentially curative treatment, without a rigid restriction to a certain chronological age.
前列腺癌影响了很大一部分 70 岁以上的男性，这些患者可能患有高危疾病，并且存在相当大的前列腺癌特异性死亡风险。随着全球预期寿命的增加，前列腺癌的负担预计也将增加。因此，有效管理这一高危老年患者群体变得日益重要。根治性前列腺切除术可以提高生存率并降低转移进展的风险。术后并发症更多地受到合并症的影响，而不是年龄的影响。在没有合并症的患者中，手术与死亡率低相关。高龄可能会增加根治性前列腺切除术后尿失禁的可能性，但与低危组相比，高危疾病患者发生这种并发症的可能性并不更高。应在考虑个体患者的健康状况和预期寿命后做出治疗决策。如果符合条件，应将根治性前列腺切除术作为一种潜在的治愈性治疗方法提供给患者，而不是严格限制在特定的年龄。
