Ascher Benjamin, Fanchon Chantal, Kanoun-Copy Leila, Bouloc Anne, Benech Florence
Clinique Iena, Paris, France.
J Cosmet Laser Ther. 2012 Oct;14(5):234-8. doi: 10.3109/14764172.2012.712700.
A monocentre double-blind two parallel group clinical study was conducted to assess whether a new skincare regimen containing retinol, adenosine and hyaluronic acid, applied after the injection of botulinum toxin A to the glabellar area, provided a beneficial effect.
Standardised photographs acquired using LifeViz cameras and zoomed pictures of the glabella and of the crow's feet areas were analysed with automatic well-defined procedures. Perceived efficacy and tolerance were also analysed by comparison between the two groups.
A beneficial effect versus placebo-treated group was proven in the group having topically applied the new skincare regimen for 2 months following botulinum toxin A injection with no touch up after 1 month. 3D image analysis showed more rapid results on D10 and enhanced efficacy on M2. Moreover, a beneficial effect independent of injection was measured in the crow's feet area, and analysis of the self-evaluation questionnaire showed enhanced efficacy perceived by the volunteers.
A specially developed skincare regimen applied immediately after botulinum toxin A injection completes the beneficial effect of the injection on the glabellar area and offers clinical benefits in fine lines, wrinkles and smoothness on the whole face.
开展了一项单中心双盲两组平行对照临床研究，以评估在眉间区域注射A型肉毒毒素后使用含视黄醇、腺苷和透明质酸的新型护肤方案是否具有有益效果。
使用LifeViz相机获取的标准化照片以及眉间和鱼尾纹区域的放大图片，通过自动明确的程序进行分析。还通过两组之间的比较分析了感知疗效和耐受性。
在注射A型肉毒毒素后局部应用新型护肤方案2个月且1个月后未进行补打的组中，证明相对于安慰剂治疗组具有有益效果。三维图像分析显示在第10天有更快的效果，在第2个月疗效增强。此外，在鱼尾纹区域测量到与注射无关的有益效果，自我评估问卷分析显示志愿者感知到疗效增强。
在注射A型肉毒毒素后立即应用专门研发的护肤方案，可完善注射对眉间区域的有益效果，并在全脸的细纹、皱纹和平滑度方面带来临床益处。
