INSERM U646, Université d’ Angers,, 40 rue de Rennes, Angers, France.
Curr Pharm Biotechnol. 2012 Sep;13(12):2388-402. doi: 10.2174/138920112803341761.
Neurodegenerative disorders (NDs) are rapidly increasing as population ages. However, successful treatments for NDs have so far been limited and drug delivery to the brain remains one of the major challenges to overcome. There has recently been growing interest in the development of drug delivery systems (DDS) for local or systemic brain administration. DDS are able to improve the pharmacological and therapeutic properties of conventional drugs and reduce their side effects. The present review provides a concise overview of the recent advances made in the field of brain drug delivery for treating neurodegenerative disorders. Examples include polymeric micro and nanoparticles, lipidic nanoparticles, pegylated liposomes, microemulsions and nanogels that have been tested in experimental models of Parkinson's, Alzheimer's and Huntington's disease. Overall, the results reviewed here show that DDS have great potential for NDs treatment.
神经退行性疾病（NDs）随着人口老龄化而迅速增加。然而，迄今为止，针对 NDs 的有效治疗方法十分有限，且向大脑输送药物仍然是需要克服的主要挑战之一。最近，人们对开发用于局部或全身脑内给药的药物输送系统（DDS）越来越感兴趣。DDS 能够改善传统药物的药理学和治疗特性，并降低其副作用。本综述简要概述了在治疗神经退行性疾病的脑内药物输送领域的最新进展。例如，已经在帕金森病、阿尔茨海默病和亨廷顿病的实验模型中测试了聚合物微球和纳米颗粒、脂质体纳米颗粒、聚乙二醇化脂质体、微乳液和纳米凝胶等。总的来说，这里综述的结果表明，DDS 对 NDs 的治疗具有很大的潜力。
