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68Ga-DOTATATE PET/CT 用于检测大动脉炎症：与 18F-FDG、钙负荷和危险因素的相关性。

68Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with18F-FDG, calcium burden and risk factors.

机构信息

Department of Nuclear Medicine, University of Wuerzburg, Oberdürrbacher Str, 6, Wuerzburg, D-97080, Germany.

出版信息

EJNMMI Res. 2012 Sep 27;2(1):52. doi: 10.1186/2191-219X-2-52.

DOI:10.1186/2191-219X-2-52
PMID:23016793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3475087/
Abstract

BACKGROUND: Ga-[1,4,7,10-tetraazacyclododecane-N,N',N″,N'″-tetraacetic acid]-d-Phe1,Tyr3-octreotate (DOTATATE) positron emission tomography (PET) is commonly used for the visualization of somatostatin receptor (SSTR)-positive neuroendocrine tumors. SSTR is also known to be expressed on macrophages, which play a major role in inflammatory processes in the walls of coronary arteries and large vessels. Therefore, imaging SSTR expression has the potential to visualize vulnerable plaques. We assessed 68Ga-DOTATATE accumulation in large vessels in comparison to 18F-2-fluorodeoxyglucose (FDG) uptake, calcified plaques (CPs), and cardiovascular risk factors. METHODS: Sixteen consecutive patients with neuroendocrine tumors or thyroid cancer underwent both 68Ga-DOTATATE and 18F-FDG PET/CT for staging or restaging purposes. Detailed clinical data, including common cardiovascular risk factors, were recorded. For a separate assessment, they were divided into a high-risk and a low-risk group. In each patient, we calculated the maximum target-to-background ratio (TBR) of eight arterial segments. The correlation of the TBRmean of both tracers with risk factors including plaque burden was assessed. RESULTS: The mean TBR of 68Ga-DOTATATE in all large arteries correlated significantly with the presence of CPs (r = 0.52; p < 0.05), hypertension (r = 0.60; p < 0.05), age (r = 0.56; p < 0.05), and uptake of 18F-FDG (r = 0.64; p < 0.01). There was one significant correlation between 18F-FDG uptake and hypertension (0.58; p < 0.05). Out of the 37 sites with the highest focal 68Ga-DOTATATE uptake, 16 (43.2%) also had focal 18F-FDG uptake. Of 39 sites with the highest 18F-FDG uptake, only 11 (28.2%) had a colocalized 68Ga-DOTATATE accumulation. CONCLUSIONS: In this series of cancer patients, we found a stronger association of increased 68Ga-DOTATATE uptake with known risk factors of cardiovascular disease as compared to 18F-FDG, suggesting a potential role for plaque imaging in large arteries. Strikingly, we found that focal uptake of 68Ga-DOTATATE and 18F-FDG does not colocalize in a significant number of lesions.

摘要

背景：Ga-[1,4,7,10-四氮杂环十二烷-N,N',N″,N'″-四乙酸]-D-Phe1,Tyr3-奥曲肽（DOTATATE）正电子发射断层扫描（PET）常用于可视化生长抑素受体（SSTR）阳性神经内分泌肿瘤。SSTR 也已知在巨噬细胞上表达，巨噬细胞在冠状动脉和大血管壁的炎症过程中发挥主要作用。因此，成像 SSTR 表达有可能可视化易损斑块。我们评估了 68Ga-DOTATATE 在大血管中的积聚与 18F-2-氟脱氧葡萄糖（FDG）摄取、钙化斑块（CPs）和心血管危险因素的关系。

方法：16 例连续的神经内分泌肿瘤或甲状腺癌患者接受了 68Ga-DOTATATE 和 18F-FDG PET/CT 分期或重新分期。记录了详细的临床数据，包括常见的心血管危险因素。为了单独评估，他们被分为高风险组和低风险组。在每个患者中，我们计算了八个动脉节段的最大靶标与背景比（TBR）。评估了两种示踪剂的 TBRmean 与包括斑块负担在内的危险因素的相关性。

结果：所有大动脉的 68Ga-DOTATATE 平均 TBR 与 CPs 的存在呈显著相关（r=0.52；p<0.05）、高血压（r=0.60；p<0.05）、年龄（r=0.56；p<0.05）和 18F-FDG 摄取（r=0.64；p<0.01）。18F-FDG 摄取与高血压之间存在唯一显著相关性（0.58；p<0.05）。在 68Ga-DOTATATE 摄取最高的 37 个部位中，有 16 个（43.2%）也有 18F-FDG 摄取。在 18F-FDG 摄取最高的 39 个部位中，只有 11 个（28.2%）有 68Ga-DOTATATE 的聚集。

结论：在这一系列癌症患者中，我们发现与心血管疾病已知危险因素相比，68Ga-DOTATATE 摄取的增加与 18F-FDG 有更强的关联，这表明在大动脉中斑块成像可能具有潜在作用。引人注目的是，我们发现 68Ga-DOTATATE 和 18F-FDG 的局灶性摄取在大量病变中没有明显的聚集。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/1a9a1ada2157/2191-219X-2-52-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/bf380f1e6495/2191-219X-2-52-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/2bbaaa6fc2d4/2191-219X-2-52-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/ddb8f5b9a996/2191-219X-2-52-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/236fe9be0dfd/2191-219X-2-52-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/1a9a1ada2157/2191-219X-2-52-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/bf380f1e6495/2191-219X-2-52-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/2bbaaa6fc2d4/2191-219X-2-52-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/ddb8f5b9a996/2191-219X-2-52-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/236fe9be0dfd/2191-219X-2-52-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee2/3475087/1a9a1ada2157/2191-219X-2-52-5.jpg

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