Yang Yang, Li Shu-Jun, Pan Jing-Jing, Hu Yu-Hua, Zhou Xiao-Yu, Cheng Rui, Chen Xiao-Qing
Department of Neonates, Children's Hospital of Nanjing Medical University, Nanjing, China.
Department of Pediatrics, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
J Paediatr Child Health. 2018 Mar;54(3):284-288. doi: 10.1111/jpc.13732. Epub 2017 Sep 28.
To determine the level of cystatin C (Cys-C) values in preterm babies for the purpose of becoming a good endogenous marker of renal function.
A total of 366 very low-birthweight infants (including 70 extremely low-birthweight babies) with gestational age <37 weeks born in two centres were studied.
In very low-birthweight infants, the mean level of Cys-C was 1.96 ± 0.44 mg/L in blood samples taken on day 1, 1.78 ± 0.49 mg/L on day 7 and 1.71 ± 0.47 mg/L on day 28. In extremely low-birthweight infants, the mean level of Cys-C was 2.00 ± 0.49 mg/L on day 1, 1.63 ± 0.38 mg/L on day 7 and 1.62 ± 0.55 mg/L on day 28, respectively. Compared to serum creatinine and blood urea nitrogen, Cys-C level was independent of birthweight and gestational age.
Cys-C is regarded as an alternative for assessing renal function in very low-birthweight infants, but its advantages over serum creatinine and blood urea nitrogen has not been fully proved yet. Hence, larger sample study is still necessary.
测定早产儿胱抑素C（Cys-C）水平，以使其成为肾功能良好的内源性标志物。
对两个中心出生的366例胎龄<37周的极低出生体重儿（包括70例超低出生体重儿）进行研究。
在极低出生体重儿中，出生第1天采集的血样中Cys-C平均水平为1.96±0.44mg/L，第7天为1.78±0.49mg/L，第28天为1.71±0.47mg/L。在超低出生体重儿中，Cys-C平均水平第1天为2.00±0.49mg/L，第7天为1.63±0.38mg/L，第28天为1.62±0.55mg/L。与血清肌酐和血尿素氮相比，Cys-C水平与出生体重和胎龄无关。
Cys-C被视为评估极低出生体重儿肾功能的替代指标，但其相对于血清肌酐和血尿素氮的优势尚未得到充分证实。因此，仍有必要进行更大样本的研究。
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