Department of Microbiology & Immunology, Virginia Commonwealth University, Massey Cancer Center, Richmond, Virginia 232989, USA.
Immunol Invest. 2012;41(6-7):711-21. doi: 10.3109/08820139.2012.673670.
Myeloid-derived suppressor cells (MDSCs) were initially reported as suppressor of the adaptive immune responses against cancer and other diseases. However, emerging evidence suggest that MDSCs may also support anti-tumor immune responses under certain conditions or may inhibit tumor growth. In the present mini-review, we suggest that such opposing functions of MDSCs are due to phenotypic plasticity of the myeloid cells, allowing them to produce a diverse form of morphology, physiological state, and function in response to environmental conditions. Therefore, they can be manipulated by means of immune modulators to overcome their immune suppressive function.
髓系来源的抑制细胞（MDSCs）最初被报道为抑制对癌症和其他疾病的适应性免疫反应。然而，新出现的证据表明，在某些条件下，MDSCs 也可能支持抗肿瘤免疫反应，或者可能抑制肿瘤生长。在本综述中，我们提出，MDSCs 的这种相反功能是由于髓样细胞的表型可塑性，使它们能够根据环境条件产生不同形式的形态、生理状态和功能。因此，可以通过免疫调节剂来操纵它们，以克服其免疫抑制功能。
