Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
Vitam Horm. 2012;90:163-86. doi: 10.1016/B978-0-12-398313-8.00007-5.
Maintenance of energy metabolism and glucose homeostasis is achieved by the regulatory effects of many hormones and their interactions. Glucocorticoids produced from adrenal cortex and adiponectin produced by adipose tissue play important roles in the production, distribution, storage, and utilization of energy substrates. Glucocorticoids are involved in the activation of a number of catabolic processes by affecting the expression of a plethora of genes, while adiponectin acts primarily as an insulin sensitizer. Both are regulated by a number of physiological and pharmacological factors. Although the effects of glucocorticoids on adiponectin expression have been extensively studied in different in vitro, animal and clinical study settings, no consensus has been reached. This report reviews the primary literature concerning the effects of glucocorticoids on adiponectin expression and identifies potential reasons for the contradictory results between different studies. In addition, methods to gain better insights pertaining to the regulation of adiponectin expression are discussed.
能量代谢和葡萄糖稳态的维持是通过许多激素的调节作用及其相互作用实现的。肾上腺皮质产生的糖皮质激素和脂肪组织产生的脂联素在能量底物的产生、分布、储存和利用中发挥重要作用。糖皮质激素通过影响大量基因的表达，参与多种分解代谢过程的激活，而脂联素主要作为胰岛素增敏剂发挥作用。两者都受到许多生理和药理因素的调节。尽管糖皮质激素对脂联素表达的影响在不同的体外、动物和临床研究环境中已经得到了广泛的研究，但尚未达成共识。本报告综述了关于糖皮质激素对脂联素表达影响的主要文献，并确定了不同研究结果之间存在矛盾的潜在原因。此外，还讨论了获得关于脂联素表达调控的更好认识的方法。
