Manani G, Osti M P, Simini G, Costa G, Piccinni P, Giron G P
Ann Anesthesiol Fr. 1977;18(10):783-90.
The authors studied the effects of flunitrazepam, trazodone and sulpiride on recovery reactions following ketamine anaesthesia, in male patients aged between 15 and 25 years, following minor orthopaedic surgery. Only flunitrazepam and trazodone proved to be effective, whilst sulpiride was quite useless in the prevention of recovery reactions. The authors nevertheless feel that trazodone is preferable to flunitrazepam since it reduces all recovery reactions and, in particular, because it reduces the agitation induced by ketamine, rendering the pseudo-hallucinations pleasant, and because it is free of the hypnotic component of flunitrazepam, often inconstant and sometimes responsible for the patient swallowing his tongue.
作者研究了氟硝西泮、曲唑酮和舒必利对15至25岁男性患者在接受小骨科手术后氯胺酮麻醉后恢复反应的影响。结果表明，只有氟硝西泮和曲唑酮有效，而舒必利在预防恢复反应方面毫无用处。然而，作者认为曲唑酮比氟硝西泮更可取，因为它能减轻所有恢复反应，特别是能减轻氯胺酮引起的躁动，使假性幻觉变得令人愉悦，而且它没有氟硝西泮的催眠成分，氟硝西泮的催眠成分往往不稳定，有时还会导致患者咬舌。
