Freuchen I, Ostergaard J, Kühl J B, Mikkelsen B O
Acta Anaesthesiol Scand. 1976;20(2):97-103. doi: 10.1111/j.1399-6576.1976.tb05015.x.
A double-blind controlled trial based on 140 women undergoing abortus provocatus was employed to study whether the frequency of side effects after administration of the anaesthetic Ketalar (ketamine) could be reduced by a con-current dose of Rohypnol (flunitrazepam). The control group was given ketamine alone. The dosage of ketamine was 2 mg/kg body weight, supplemented if necessary by 1 mg/kg, in combination with either 2 mg flunitrazepam or placebo. No other anaesthetics were used. On several counts, the combination of ketamine and flunitrazepam was proved to reduce the adverse reactions seen with ketamine alone. Motor restlessness and confusion in the awakening state occurred with significantly less severity and frequency. Amnesia for dreams was significantly more frequent. Memory of dreams was often unpleasant after ketamine alone. The influence on pulse rate was significantly smaller and no significant changes in systolic blood pressure were seen, whereas a significant increase occurred with ketamine alone. Less pronounced fluctuations in diastolic blood pressure occurred with the combination ketamine-flunitrazepam. Respiratory rate increased significantly with both treatments, but respiratory minute volume was lower with the ketamine-flunitrazepam combination.
一项基于140名接受人工流产的女性的双盲对照试验，旨在研究同时服用氟硝西泮（罗眠乐）是否可以降低麻醉剂氯胺酮给药后的副作用发生率。对照组仅给予氯胺酮。氯胺酮的剂量为2mg/kg体重，必要时补充1mg/kg，并与2mg氟硝西泮或安慰剂联合使用。未使用其他麻醉剂。在几个方面，氯胺酮和氟硝西泮的组合被证明可以减少单独使用氯胺酮时出现的不良反应。觉醒状态下的运动不安和意识模糊的严重程度和发生率明显降低。梦境遗忘明显更频繁。单独使用氯胺酮后，对梦境的记忆往往不愉快。对脉搏率的影响明显较小，收缩压未见明显变化，而单独使用氯胺酮时收缩压显著升高。氯胺酮-氟硝西泮组合时舒张压的波动较小。两种治疗方法均使呼吸频率显著增加，但氯胺酮-氟硝西泮组合时每分钟通气量较低。
