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重温皮肤网状色素沉着障碍谱。

The spectrum of reticulate pigment disorders of the skin revisited.

机构信息

Department of Dermatology, Saarland University Hospital, Kirrberger Str., 66421 Homburg/Saar, Germany.

出版信息

Eur J Dermatol. 2012 Sep-Oct;22(5):596-604. doi: 10.1684/ejd.2012.1829.

Abstract

Within the group of classical reticulate pigment disorders of the skin, Galli-Galli disease (GGD), Dowling-Degos disease (DDD), Kitamura's disease (RPK), Haber's syndrome (HS), and reticulate acropigmentation of Dohi (RAD) are included and distinguished clinically and histopathologically. The clinical appearance of the reticulate pigment disorders of the skin is similar, with slight differences in age of onset and associated disorders. The histopathologic features of reticulate pigment disorders of the skin are comparable, with the exception of the unique hallmark of suprabasal acantholysis, which can be observed exclusively in GGD. Based on a critical discussion, we recommend using major and minor defining criteria for diagnosing skin lesions compatible with the reticulate pigment dermatoses of the skin. Herein we discuss a unifying nosological concept to provide straightforward diagnoses of the reticulate pigment disorders of the skin with a therapeutic impact.

摘要

在皮肤的经典网状色素沉着障碍组中,包括 Galli-Galli 病(GGD)、Dowling-Degos 病(DDD)、Kitamura 病(RPK)、Haber 综合征(HS)和 Dohi 的网状肢端色素沉着(RAD),并在临床上和组织病理学上进行区分。皮肤网状色素沉着障碍的临床表现相似,发病年龄和相关疾病略有不同。皮肤网状色素沉着障碍的组织病理学特征相似,除了 GGD 中独有的棘层松解的独特标志外。基于批判性讨论,我们建议使用主要和次要诊断标准来诊断与皮肤网状色素沉着病相符的皮肤病变。在此,我们讨论了一个统一的分类学概念,为皮肤网状色素沉着障碍提供了具有治疗意义的直接诊断。

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