Dermatology Department, Faculty of Medicine, Cairo University, 13th Abrag Othman, Kornish El Maadi, Cairo 11431, Egypt.
Eur J Dermatol. 2012 Sep-Oct;22(5):645-50. doi: 10.1684/ejd.2012.1830.
Laser-assisted hair removal causes miniaturization of hair shafts which are the principal contributors to inflammation in acne keloidalis nuchae (AKN).
To assess the efficacy of hair reduction by long pulsed Nd-YAG laser as a therapeutic modality for AKN.
This interventional pilot trial included 16 patients with AKN who received 5 sessions of long pulsed Nd-YAG laser. Lesions were objectively and subjectively assessed at the third and fifth laser sessions, and 1 year after. Global response to treatment was rated using a quartile grading scale regarding the percentage improvement in the count of papules and the size of the plaques. Biopsies were taken before and 2 weeks after the fifth session to evaluate the pathological changes associated with improvement of the treated lesions.
All patients showed a significant improvement. The percentage of improvement in the early caseswas significantly higher when compared to late cases.Two weeks after the fifth session, all biopsies showed a significant decrease in the inflammatory infiltrate except one case. Sclerosis was markedly decreased. Complete absence of hair follicles and adenexawas observed, apart from in 2 cases.
Laser hair depilation can significantly improve this disfiguring chronic disorder. Starting treatment as early as possible achieves the best results and can stop the disease process if followed by maintenance sessions.
激光脱毛会导致毛囊缩小,而毛囊是导致穿凿性毛囊性瘢痕性毛囊炎(AKN)炎症的主要原因。
评估长脉冲 Nd-YAG 激光减少脱发作为 AKN 治疗方法的疗效。
这项干预性试点试验纳入了 16 名 AKN 患者,他们接受了 5 次长脉冲 Nd-YAG 激光治疗。在第三次和第五次激光治疗时以及 1 年后,对病变进行了客观和主观评估。使用四分位数分级量表,根据丘疹数量和斑块大小的改善百分比,对治疗效果进行整体评价。在第五次治疗前和治疗后 2 周取活检,以评估与治疗病变改善相关的病理变化。
所有患者均有明显改善。与晚期病例相比,早期病例的改善百分比明显更高。第五次治疗后 2 周,除 1 例外,所有活检均显示炎症浸润显著减少。硬化明显减少。除 2 例外,还观察到毛囊和附属器完全缺失。
激光脱毛可显著改善这种影响容貌的慢性疾病。尽早开始治疗可获得最佳效果,如果随后进行维持治疗,可以阻止疾病进程。