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瘢痕疙瘩性痤疮的治疗:文献系统评价

Treatment of Acne Keloidalis Nuchae: A Systematic Review of the Literature.

作者信息

Maranda Eric L, Simmons Brian J, Nguyen Austin H, Lim Victoria M, Keri Jonette E

机构信息

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Creighton University School of Medicine, Omaha, NE, USA.

出版信息

Dermatol Ther (Heidelb). 2016 Sep;6(3):363-78. doi: 10.1007/s13555-016-0134-5. Epub 2016 Jul 18.

Abstract

Acne keloidalis nuchae (AKN) is a chronic inflammatory condition that leads to fibrotic plaques, papules and alopecia on the occiput and/or nape of the neck. Traditional medical management focuses on prevention, utilization of oral and topical antibiotics, and intralesional steroids in order to decrease inflammation and secondary infections. Unfortunately, therapy may require months of treatment to achieve incomplete results and recurrences are common. Surgical approach to treatment of lesions is invasive, may require general anesthesia and requires more time to recover. Light and laser therapies offer an alternative treatment for AKN. The present study systematically reviews the currently available literature on the treatment of AKN. While all modalities are discussed, light and laser therapy is emphasized due to its relatively unknown role in clinical management of AKN. The most studied modalities in the literature were the 1064-nm neodymium-doped yttrium aluminum garnet laser, 810-nm diode laser, and CO2 laser, which allow for 82-95% improvement in 1-5 sessions. Moreover, side effects were minimal with transient erythema and mild burning being the most common. Overall, further larger-scale randomized head to head control trials are needed to determine optimal treatments.

摘要

瘢痕疙瘩性痤疮(AKN)是一种慢性炎症性疾病,可导致枕部和/或颈部后颈出现纤维化斑块、丘疹和脱发。传统医学治疗主要侧重于预防,使用口服和外用抗生素以及病灶内注射类固醇,以减轻炎症和继发性感染。不幸的是,治疗可能需要数月时间,效果并不完全,且复发很常见。手术治疗病变具有侵入性,可能需要全身麻醉,恢复时间也更长。光疗和激光疗法为AKN提供了另一种治疗选择。本研究系统回顾了目前关于AKN治疗的可用文献。虽然讨论了所有治疗方式,但由于光疗和激光疗法在AKN临床管理中的作用相对不为人知,因此重点强调了这两种疗法。文献中研究最多的治疗方式是1064纳米掺钕钇铝石榴石激光、810纳米二极管激光和二氧化碳激光,在1至5次治疗后可使病情改善82%至95%。此外,副作用最小,最常见的是短暂性红斑和轻度烧灼感。总体而言,需要进一步进行更大规模的随机对照试验来确定最佳治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ea2/4972740/de389a23eb90/13555_2016_134_Fig1_HTML.jpg

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