Honda Shohei, Miyagi Hisayuki, Minato Masashi, Kubota Kanako C, Okada Tadao
Department of Pediatric Surgery, Hokkaido University Hospital, Sapporo, Japan.
J Pediatr Hematol Oncol. 2012 Nov;34(8):635-7. doi: 10.1097/MPH.0b013e3182678e1e.
Spontaneous rupture of adrenal neuroblastoma is very rare in infants, in contrast to neonates. This report describes a 9-month-old boy presenting with acute hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma. MYCN oncogene amplification may be a predisposing factor for spontaneous rupture and bleeding of neuroblastoma. An appropriate surgical treatment for this condition must be discussed according to the patient's general state and the tumor features, such as staging, the origin, and local invasiveness.
与新生儿相比,肾上腺神经母细胞瘤在婴儿中自发破裂非常罕见。本报告描述了一名9个月大的男孩,因肾上腺神经母细胞瘤自发破裂而出现急性失血性休克。MYCN癌基因扩增可能是神经母细胞瘤自发破裂和出血的一个诱发因素。必须根据患者的一般状况和肿瘤特征,如分期、起源和局部侵袭性,来讨论针对这种情况的适当手术治疗方法。