发生慢性排斥反应的尸体肾移植受者的特征
Characteristics of cadaveric renal allograft recipients developing chronic rejection.
作者信息
Foster M C, Rowe P A, Dennis M J, Morgan A G, Burden R P, Blamey R W
机构信息
Department of Surgery, City Hospital, Nottingham.
出版信息
Ann R Coll Surg Engl. 1990 Jan;72(1):23-6.
As the early results of renal transplantation improve, chronic rejection is increasing in relative importance as a cause of graft loss. The aetiology of the condition is unknown. In order to identify possible predisposing factors, the characteristics of 22 patients with chronic rejection were compared with those of 50 patients with stable graft function 2 years or more after transplantation. Patients with chronic rejection had significantly more acute rejection episodes in the first 6 months after transplant (P less than 0.01), a higher incidence of acute rejection with vascular features (P less than 0.01), and longer ischaemic times (P less than 0.05) compared to patients with stable graft function. In a logistic regression analysis both frequency and severity of acute rejection episodes were significantly associated with the subsequent development of chronic rejection. Thus chronic rejection is associated with early injury to the transplanted kidney.
随着肾移植早期结果的改善，作为移植肾丢失的一个原因，慢性排斥反应的相对重要性日益增加。该病的病因尚不清楚。为了确定可能的易感因素，将22例慢性排斥反应患者的特征与50例移植后2年或更长时间移植肾功能稳定患者的特征进行了比较。与移植肾功能稳定的患者相比，慢性排斥反应患者在移植后的前6个月有明显更多的急性排斥反应发作（P<0.01），急性排斥反应伴血管特征的发生率更高（P<0.01），缺血时间更长（P<0.05）。在逻辑回归分析中，急性排斥反应发作的频率和严重程度均与慢性排斥反应的后续发展显著相关。因此，慢性排斥反应与移植肾的早期损伤有关。
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