Rosman J B, ter Wee P M, Meijer S, Piers-Becht T P, Sluiter W J, Donker A J
Lancet. 1984 Dec 8;2(8415):1291-6. doi: 10.1016/s0140-6736(84)90818-3.
In a prospective randomised study of 228 patients with various renal diseases, early moderate dietary protein restriction retarded the development of end-stage renal failure. 149 patients were followed up for at least 18 months; the protein-restricted patients showed falls in serum urea and phosphate concentrations and in the 24 h excretion of urea, phosphate, and protein. Regression analysis of the reciprocals of serum creatinine against time showed that the average rate of decrease in reciprocal creatinine was three to five times lower in the protein-restricted groups than in the control groups. These results confirm that moderate dietary protein restriction is an acceptable and effective way of delaying functional renal deterioration. The finding has implications for the management of chronic renal insufficiency.
在一项针对228例患有各种肾脏疾病患者的前瞻性随机研究中，早期适度的饮食蛋白质限制延缓了终末期肾衰竭的发展。149例患者接受了至少18个月的随访；蛋白质限制组患者的血清尿素和磷酸盐浓度以及24小时尿素、磷酸盐和蛋白质排泄量均有所下降。血清肌酐倒数与时间的回归分析表明，蛋白质限制组肌酐倒数的平均下降速率比对照组低三至五倍。这些结果证实，适度的饮食蛋白质限制是延缓肾功能恶化的一种可接受且有效的方法。这一发现对慢性肾功能不全的管理具有重要意义。
