Guang Hui-Juan, Li Zheng, Wang Yi-Peng, Lai Ren, Yu Hai-Ning
School of Life Science and Biotechnology, Dalian University of Technology, China.
Dongwuxue Yanjiu. 2012 Oct;33(5):523-6. doi: 10.3724/SP.J.1141.2012.05523.
Cathelicidins are a family of multi-functional antimicrobial peptides found in almost all types of vertebrates, where they play vital roles in the immune system. As they possess broad-spectrum antimicrobial properties, cathelicidins are not only strongly resistant to Gram-positive and Gram-negative bacteria, fungi, and viruses, but they are also active against many antibiotic-resistant clinical bacteria, adopting a special antimicrobial mechanism that is unlikely to lead to microbial resistance. Cathelicidins likewise possess simple structures, and low hemolytic and cytotoxic activities. Collectively, these features suggest potentially novel and exciting prospects for cathelicidins' application in medicine. Here, we review the structures, classification, activities, mechanisms, as well as prospective developments in the usage and application of cathelicidin antimicrobial peptides.
cathelicidin是一类多功能抗菌肽，几乎存在于所有类型的脊椎动物中，在免疫系统中发挥着至关重要的作用。由于它们具有广谱抗菌特性，cathelicidin不仅对革兰氏阳性菌和革兰氏阴性菌、真菌和病毒具有很强的抗性，而且对许多耐抗生素的临床细菌也有活性，采用一种特殊的抗菌机制，不太可能导致微生物产生抗性。Cathelicidin同样具有简单的结构，以及低溶血和细胞毒性活性。总的来说，这些特性表明cathelicidin在医学应用方面具有潜在的新颖和令人兴奋的前景。在此，我们综述了cathelicidin抗菌肽的结构、分类、活性、作用机制以及使用和应用方面的前瞻性发展。
