Kang Hee-Kyoung, Kim Cheolmin, Seo Chang Ho, Park Yoonkyung
Department of Biomedical Sciences, Chosun University, Gwangju, 61452, Republic of Korea.
Department of Bioinformatics, Kongju National University, Kongju, 32588, Republic of Korea.
J Microbiol. 2017 Jan;55(1):1-12. doi: 10.1007/s12275-017-6452-1. Epub 2016 Dec 30.
Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in addition to anti-inflammatory and immunomodulatory activities. Therefore, AMPs have garnered interest as novel therapeutic agents. Because of the rapid increase in drug-resistant pathogenic microorganisms, AMPs from synthetic and natural sources have been developed using alternative antimicrobial strategies. This article presents a broad analysis of patents referring to the therapeutic applications of AMPs since 2009. The review focuses on the universal trends in the effective design, mechanism, and biological evolution of AMPs.
抗菌肽（AMPs）是一类小分子，除了具有抗炎和免疫调节活性外，还对细菌、酵母、真菌和病毒具有广谱抗生素活性，并且对癌细胞具有细胞毒性活性。因此，抗菌肽作为新型治疗剂引起了人们的关注。由于耐药致病微生物迅速增加，已采用替代抗菌策略开发了来自合成和天然来源的抗菌肽。本文对自2009年以来涉及抗菌肽治疗应用的专利进行了广泛分析。该综述重点关注抗菌肽有效设计、作用机制和生物进化的普遍趋势。
