Shi Shuaibing, Shen Tengfei, Liu Yongqing, Chen Liangliang, Wang Chen, Liao Chengshui
The Key Lab of Veterinary Biological Products, Henan University of Science and Technology, Luoyang, China.
College of Animal Science and Technology/Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, China.
Front Vet Sci. 2021 May 14;8:664139. doi: 10.3389/fvets.2021.664139. eCollection 2021.
Traditional antibiotics have made great contributions to human health and animal husbandry since the discovery of penicillin in 1928, but bacterial resistance and drug residues are growing threats to global public health due to the long-term uncontrolled application of antibiotics. There is a critical need to develop new antimicrobial drugs to replace antibiotics. Antimicrobial peptides (AMPs) are distributed in all kingdoms of life, presenting activity against pathogens as well as anticancer, anti-inflammatory, and immunomodulatory activities; consequently, they have prospects as new potential alternatives to antibiotics. Porcine myeloid antimicrobial peptides (PMAPs), the porcine cathelicidin family of AMPs, have been reported in the literature in recent years. PMAPs have become an important research topic due to their strong antibacterial activity. This review focuses on the universal trends in the biochemical parameters, structural characteristics and biological activities of PMAPs.
自1928年青霉素被发现以来，传统抗生素对人类健康和畜牧业做出了巨大贡献，但由于抗生素的长期无节制使用，细菌耐药性和药物残留对全球公共卫生构成了日益严重的威胁。迫切需要开发新的抗菌药物来替代抗生素。抗菌肽（AMPs）分布于所有生物界，具有抗病原体活性以及抗癌、抗炎和免疫调节活性；因此，它们有望成为抗生素的新潜在替代品。猪髓系抗菌肽（PMAPs）是猪抗菌肽家族中的cathelicidin，近年来已在文献中有所报道。由于其强大的抗菌活性，PMAPs已成为一个重要的研究课题。本综述重点关注PMAPs的生化参数、结构特征和生物活性的普遍趋势。
