Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Beilstein J Org Chem. 2012;8:1536-42. doi: 10.3762/bjoc.8.174. Epub 2012 Sep 14.
Direct C2-alkylation of an indole bearing a readily removable N-pyrimidyl group with a vinylsilane was achieved by using a cobalt catalyst generated in situ from CoBr(2), bathocuproine, and cyclohexylmagnesium bromide. The reaction allows coupling between a series of N-pyrimidylindoles and vinylsilanes at a mild reaction temperature of 60 °C, affording the corresponding alkylated indoles in moderate to good yields.
通过使用钴(II)溴化物、苯并菲和环己基溴化镁原位生成的钴催化剂，实现了带有易于去除的 N-嘧啶基的吲哚与乙烯基硅烷的直接 C2-烷基化反应。该反应在温和的反应温度 60°C 下允许一系列 N-嘧啶吲哚和乙烯基硅烷之间进行偶联，以中等至良好的收率得到相应的烷基化吲哚。
