实验性迷走神经干切断术对血清胃泌素浓度的急性影响。
Acute effect of experimental truncal vagotomy on serum gastrin concentrations.
作者信息
Lee S K, Thirlby R C, Thompson W, Walsh J H, Feldman M
机构信息
Medical Service, Veterans Administration Medical Center, Dallas, Texas.
出版信息
Ann Surg. 1990 Feb;211(2):136-40. doi: 10.1097/00000658-199002000-00004.
We studied the acute effect of transthoracic truncal vagotomy or sham vagotomy (control) on fasting serum gastrin concentrations in 22 gastric fistula dogs. A significant (p less than 0.05) decrease in serum gastrin concentration was detectable within 2.5 minutes after truncal vagotomy, and by 120 minutes serum gastrin has decreased to 15 +/- 1 pg/mL in the vagotomy group compared to 28 +/- 3 pg/mL in the control group (p less than 0.001). However by 24 hours after vagotomy, when maximal acid output was reduced by approximately 50%, fasting serum gastrin had increased nearly twofold above control levels in the vagotomy group (p = 0.06) and this increase persisted at day 7 (p less than 0.05). Thus truncal vagotomy had a biphasic effect on serum gastrin concentrations in dogs (acute inhibition followed by stimulation). While the mechanism for the acute fall in gastrin is probably an acute denervation of postganglionic neurons that innervate gastrin cells, the mechanism for the subsequent rise in serum gastrin remains uncertain.
我们研究了经胸迷走神经干切断术或假迷走神经切断术（对照）对22只胃瘘犬空腹血清胃泌素浓度的急性影响。迷走神经干切断术后2.5分钟内可检测到血清胃泌素浓度显著降低（p<0.05），到120分钟时，迷走神经切断术组血清胃泌素降至15±1 pg/mL，而对照组为28±3 pg/mL（p<0.001）。然而，迷走神经切断术后24小时，当最大胃酸分泌量降低约50%时，迷走神经切断术组空腹血清胃泌素比对照组水平增加了近两倍（p = 0.06），且这种增加在第7天持续存在（p<0.05）。因此，迷走神经干切断术对犬血清胃泌素浓度有双相作用（急性抑制后刺激）。虽然胃泌素急性下降的机制可能是支配胃泌素细胞的节后神经元急性去神经支配，但血清胃泌素随后升高的机制仍不确定。
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