Depto. Fisiologia Facultad de Medicina, Universidad Nacional Autonoma de Mexico. Apdo, Postal 70-250, Mexico D.F. 04510, Mexico.
Neurosci Lett. 2012 Nov 7;529(2):118-22. doi: 10.1016/j.neulet.2012.09.037. Epub 2012 Sep 27.
During the process of a brain injury, responses to produce damage and cell death are activated, but self-protective responses that attempt to maintain the integrity and functionality of the brain are also activated. We have previously reported that the recovery from a traumatic brain injury (TBI) is better in rats if it occurs during the dark phase of the diurnal cycle when rats are in the waking period. This suggests that wakefulness causes a neuroprotective role in this type of injury. Here we report that 24h of total sleep deprivation after a TBI reduces the morphological damage and enhances the recovery of the rats, as seen on a neurobiological scale.
在脑损伤过程中，会激活导致损伤和细胞死亡的反应，但也会激活试图维持大脑完整性和功能的自我保护反应。我们之前曾报道过，如果创伤性脑损伤 (TBI) 发生在大鼠白天的清醒期的夜间周期的黑暗阶段，大鼠的恢复情况会更好。这表明清醒状态在这种类型的损伤中起到了神经保护作用。在这里，我们报告说，TBI 后进行 24 小时的完全睡眠剥夺会减少大鼠的形态损伤，并增强其恢复，从神经生物学角度来看是这样的。
