Estrada-Rojo Francisco, Morales-Gomez Julio, Coballase-Urrutia Elvia, Martinez-Vargas Marina, Navarro Luz
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.
Programa de Posgrado en Ciencias Biologicas, Universidad Nacional Autonoma de México, Mexico City, Mexico.
BMC Res Notes. 2018 Feb 21;11(1):150. doi: 10.1186/s13104-018-3258-0.
Data from our laboratory suggest that recovery from a traumatic brain injury depends on the time of day at which it occurred. In this study, we examined whether traumatic brain injury -induced damage is related to circadian variation in N-methyl-D-aspartate receptor expression in rat cortex.
We confirmed that traumatic brain injury recovery depended on the time of day at which the damage occurred. We also found that motor cortex N-methyl-D-aspartate receptor subunit NR1 expression exhibited diurnal variation in both control and traumatic brain injury-subjected rats. However, this rhythm is more pronounced in traumatic brain injury-subjected rats, with minimum expression in those injured during nighttime hours. These findings suggest that traumatic brain injury occurrence times should be considered in future clinical studies and when designing neuroprotective strategies for patients.
我们实验室的数据表明，创伤性脑损伤的恢复取决于损伤发生的时间。在本研究中，我们检测了创伤性脑损伤诱导的损伤是否与大鼠皮质中N-甲基-D-天冬氨酸受体表达的昼夜变化有关。
我们证实创伤性脑损伤的恢复取决于损伤发生的时间。我们还发现，在对照组和创伤性脑损伤大鼠中，运动皮质N-甲基-D-天冬氨酸受体亚基NR1的表达均呈现昼夜变化。然而，这种节律在创伤性脑损伤大鼠中更为明显，在夜间受伤的大鼠中表达最低。这些发现表明，在未来的临床研究以及为患者设计神经保护策略时，应考虑创伤性脑损伤的发生时间。
