Department of Pharmacy, GRD (PG) IMT, Rajpur road, Dehradun, 248001, Uttarakhand, India.
J Control Release. 2012 Nov 10;163(3):353-60. doi: 10.1016/j.jconrel.2012.09.012. Epub 2012 Sep 27.
Bronchial asthma is a chronic inflammatory disorder of the airways associated with airflow obstruction that is reversible spontaneously or with treatment. Bronchial asthma is a disease based on established circadian rhythm. The symptoms of asthma worsen during midnight to early morning and therefore it is required to deliver the drug in such fashion that effective treatment can be obtained during the time of asthma attacks. Chronotherapy is an approach that fulfills the criteria of drug delivery at a specific time as per the pathophysiological need of the disease, to improve patient compliance. The current article focuses on the chronotherapy of bronchial asthma, methodologies involved for the existing systems, recent updates and different chronopharmaceutical technologies currently available in the market. Chronotherapy with different categories of bronchial asthma medications also has been reviewed.
支气管哮喘是一种气道慢性炎症性疾病，伴有气流阻塞，可自发或经治疗逆转。支气管哮喘是一种基于既定昼夜节律的疾病。哮喘症状在午夜至清晨加重，因此需要以这样的方式给药，即在哮喘发作时能够获得有效的治疗。时间治疗学是一种根据疾病的病理生理需要在特定时间给药的方法，以提高患者的依从性。本文重点介绍支气管哮喘的时间治疗学，现有的系统所涉及的方法学，最新进展以及市场上现有的不同时间药物传递技术。还对不同类别的支气管哮喘药物的时间治疗学进行了综述。
