Burioka Naoto
Division of School of Health Science, Department of Pathobiological Science and Technology, Tottori University.
Nihon Rinsho. 2013 Dec;71(12):2146-52.
Bronchial asthma is characterized by recurring symptoms, chronic inflammation of airway, reversible airflow limitation, and bronchial hyperresponsiveness. Lung function and symptoms of asthmatic patients frequently worsen between midnight and early morning. Currently, new drug delivery system based on chronopharmacology has been developed for the treatment of asthma. A night-time single dosing of anti-asthmatic drugs is clinically used for chronotherapy of asthma, which contributes to improve patient's adherence. This review focuses on chronotherapy of bronchial asthma.
支气管哮喘的特征是症状反复出现、气道慢性炎症、气流受限可逆以及支气管高反应性。哮喘患者的肺功能和症状常在午夜至清晨之间恶化。目前，基于时辰药理学的新型药物递送系统已被开发用于哮喘治疗。夜间单次服用抗哮喘药物临床上用于哮喘的时辰治疗，这有助于提高患者的依从性。本综述聚焦于支气管哮喘的时辰治疗。
