Ghaffary Mohammad Reza, Talei Ali, Moradian Maryam, Ghaffari Shamsi
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Internal Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cardiovasc Thorac Res. 2022;14(2):116-121. doi: 10.34172/jcvtr.2022.21. Epub 2022 Jun 28.
Ramadan can alter the course of diseases by changing nutrition patterns, sleep habits, and medication-taking schedules. There are some concerns that patients with asthma may be affected by these alterations during Ramadan and experience deterioration of their symptoms. This study aimed to investigate the effect of fasting in Ramadan on the severity of the disease and spirometric parameters in patients with asthma. An overall 120 patients with moderate to severe asthma were investigated during Ramadan and categorized into two groups of fasting (60 cases) and non-fasting (60 cases) groups. Patients underwent spirometry before and after Ramadan and asthma control status was also assessed. The parameters measured in spirometry were compared in each group before and after Ramadan and also between the two groups. Spirometric measurements including forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF), and FEV1/FVC were not significantly different before and after Ramadan in both groups of fasting and non-fasting patients. Furthermore, there was no significant difference between the two groups in terms of these spirometric parameters changes from baseline. Nevertheless, FEV1 change in the fasting group was significantly higher than that in the non-fasting group (1.46±5.37 vs. -0.13±3.08, respectively; =0.040). The results of this study demonstrated that fasting has no significant effect on the severity of asthma and spirometric findings in patients with moderate to severe asthma. Therefore, fasting during Ramadan can be considered safe for patients with asthma.
斋月可通过改变营养模式、睡眠习惯和服药时间表来改变疾病进程。有人担心哮喘患者在斋月期间可能会受到这些变化的影响，导致症状恶化。本研究旨在调查斋月禁食对哮喘患者疾病严重程度和肺功能参数的影响。在斋月期间，共对120例中重度哮喘患者进行了调查，并分为禁食组（60例）和非禁食组（60例）。患者在斋月前后进行了肺功能测定，并评估了哮喘控制状况。比较了每组患者在斋月前后以及两组之间肺功能测定的参数。禁食组和非禁食组患者的第一秒用力呼气量（FEV1）、用力肺活量（FVC）、呼气峰值流速（PEF）和FEV1/FVC等肺功能测量值在斋月前后均无显著差异。此外，两组在这些肺功能参数相对于基线的变化方面也没有显著差异。然而，禁食组的FEV1变化显著高于非禁食组（分别为1.46±5.37和-0.13±3.08；P=0.040）。本研究结果表明，禁食对中重度哮喘患者的哮喘严重程度和肺功能检查结果没有显著影响。因此，斋月期间禁食对哮喘患者可被视为安全。
