Turchi Stefano, Mercuri Antonella, Lazzerini Guido, Chiesa Maria Rosa, Musacchio Laura, Tozzi Sabrina, Boni Mauro, Zirilli Ottavio, Andreassi Maria Grazia
Unità Banca Biologica, Istituto di Fisiologia Clinica, Consiglio Naionale delle Richerche, Pisa.
Recenti Prog Med. 2012 Sep;103(9):307-12. doi: 10.1701/1136.12523.
Biobanks are a critical resource for "omics" technologies in order to dissect molecular mechanism and gene-environmental interactions of common diseases, such as cancer, cardiovascular diseases, diabetes, and neurodegenerative diseases. Progress in basic biomedicine may contribute to advance personalised medicine in which treatments will no longer be "one size fits all", but instead "tailored" to the molecular and genetic profile of each patient. Currently, there are major efforts worldwide to professionalize biobanks in order to move ahead from a "do-it-yourself" tissue collection - as is most frequent at present - for providing high quality preservation and storage of biological samples with potentially greater scientific impact. In this paper, we describe our recent experience in the design and development of a high-security liquid nitrogen storage system (-196°C) as a key resource for biomedical research.
生物样本库是“组学”技术的关键资源，用于剖析常见疾病（如癌症、心血管疾病、糖尿病和神经退行性疾病）的分子机制和基因-环境相互作用。基础生物医学的进展可能有助于推动个性化医疗，在这种医疗模式下，治疗将不再是“一刀切”，而是根据每个患者的分子和基因特征进行“量身定制”。目前，全球正在做出重大努力，以使生物样本库专业化，从而摆脱目前最常见的“自己动手”组织采集方式，转而提供高质量的生物样本保存和存储，这可能会产生更大的科学影响。在本文中，我们描述了我们最近在设计和开发高安全性液氮存储系统（-196°C）方面的经验，该系统是生物医学研究的关键资源。
