McMaster University, Canada; Clinical Research Clinical Trials Laboratory, Hamilton General Hospital, Hamilton, ON, Canada.
Clinical Research Clinical Trials Laboratory, Hamilton General Hospital, Hamilton, ON, Canada.
Clin Biochem. 2014 Mar;47(4-5):239-44. doi: 10.1016/j.clinbiochem.2013.11.017. Epub 2013 Dec 5.
Laboratory medicine professionals have a unique understanding of the wealth that biological samples bring to clinical research, and of the need for quality standards for the collection, transportation, storage and analytical phases. The expertise of laboratory physicians and scientists also adds value to the interpretation and publication of the results of clinical research studies. This is an account of the evolution of over thirty five years of the Biobank/Clinical Research Clinical Trials Laboratory at one Canadian health sciences centre. The logistical, financial, and quality management challenges are presented in growing from a small-scale facility to one that now stores three million well-characterized samples from more than seventy countries, representing five continents and five major ethnic groups. This is an account of a journey, it is not intended as a guide as to how to create an 'ideal' biobank. Collaboration, collegiality, consistency, creativity and clinical collaborators, are the keys to progress, but there must first be a vision, one that can expand to embrace new opportunities.
实验室医学专业人员对生物样本为临床研究带来的价值有着独特的理解，也深知生物样本在采集、运输、存储和分析阶段都需要质量标准。实验室医生和科学家的专业知识也为临床研究结果的解释和发表增添了价值。本文讲述了加拿大一个健康科学中心的生物银行/临床研究临床试验实验室三十五年多来的发展历程。从一个小规模的设施发展成为一个能够储存来自 70 多个国家、代表着五大洲和五个主要种族的 300 万份特征良好的样本的大型设施，其中涉及到物流、财务和质量管理方面的挑战。这是一段旅程的记录，它并不是如何创建一个“理想”生物库的指南。合作、协作、一致性、创造力和临床合作者是取得进展的关键，但首先必须要有一个愿景，一个能够扩大并拥抱新机遇的愿景。
