B 组链球菌定植孕妇的后续妊娠中 B 组链球菌定植与非定植孕妇的比较。
Prevalence of group B Streptococcus colonization in subsequent pregnancies of group B Streptococcus-colonized versus noncolonized women.
机构信息
Department of Obstetrics Gynecology, Wright Patterson Medical Center, Wright State University, Dayton, OH, USA.
出版信息
Am J Perinatol. 2013 May;30(5):383-8. doi: 10.1055/s-0032-1326981. Epub 2012 Sep 21.
OBJECTIVE
To determine whether group B Streptococcus (GBS)-colonized pregnant women have an increased prevalence of GBS colonization in subsequent pregnancies.
STUDY DESIGN
This retrospective cohort study compared the prevalence of GBS colonization in initial and subsequent pregnancies of 158 women with two or more deliveries at a Midwest institution since the initiation of universal screening for GBS.
RESULTS
The GBS colonization rate in index pregnancies was 20%. Colonization rate in subsequent pregnancies for initially GBS-colonized women was 42% compared with 19% for women who were not colonized with GBS in the index pregnancy (p = 0.009). The relative risk for GBS-colonized women to be GBS-colonized in subsequent pregnancies was 2.2 (confidence interval = 1.3 to 3.8).
CONCLUSION
Previous GBS colonization is a risk factor for GBS colonization in subsequent pregnancies. Consideration of intrapartum chemoprophylaxis in women with a history of GBS colonization, assuming current colonization status is unknown, warrants further investigation.
目的
确定是否患有 B 组链球菌（GBS）定植的孕妇在随后的妊娠中 GBS 定植的患病率增加。
研究设计
本回顾性队列研究比较了在中西部一家机构进行普遍 GBS 筛查后，158 名有两次或两次以上分娩的孕妇初始妊娠和后续妊娠中 GBS 定植的患病率。
结果
在指数妊娠中，GBS 定植率为 20%。在初始 GBS 定植的妇女的后续妊娠中，GBS 定植率为 42%，而在指数妊娠中未定植 GBS 的妇女为 19%（p = 0.009）。GBS 定植妇女在后续妊娠中 GBS 定植的相对风险为 2.2（置信区间为 1.3 至 3.8）。
结论
既往 GBS 定植是后续妊娠中 GBS 定植的危险因素。对于有 GBS 定植史且当前定植状态未知的妇女，考虑使用产时化学预防措施值得进一步研究。
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