Tam Teresa, Bilinski Ewa, Lombard Emily
Department of Obstetrics and Gynecology, Resurrection Health Care/Saint Joseph Hospital, Chicago, IL 60657, USA.
J Matern Fetal Neonatal Med. 2012 Oct;25(10):1987-9. doi: 10.3109/14767058.2012.670331. Epub 2012 Apr 2.
The purpose of the study is to evaluate the incidence of women with prior GBS genital colonization who have recolonization in subsequent pregnancies.
This is a retrospective, cohort study of patients with a prior GBS genital colonization in pregnancy and a subsequent pregnancy with a recorded GBS culture result, from January 2000 through June 2007. Documentation of GBS status was through GBS culture performed between 35 to 37 weeks gestation. Exclusion criteria included pregnancies with unknown GBS status, patients with GBS bacteriuria, women with a previous neonate with GBS disease and GBS finding prior to 35 weeks. Data was analyzed using SPSS 15.0. The sample proportion of subjects with GBS genital colonization and its confidence interval were computed to estimate the incidence rate. Logistic regression was performed to assess potential determinants of GBS colonization. Regression coefficients, odds ratios and associated confidence intervals, and p-values were reported, with significant results reported.
There were 371 pregnancies that met the test criteria. There were 151 subsequent pregnancies with GBS genital colonization and 220 without GBS recolonization. The incidence of GBS recolonization on patients with prior GBS genital colonization was 40.7% (95% confidence interval 35.7-45.69%). The incidence rate for the sample was significantly larger than 30% (p < .001), which is the estimated incidence rate for all pregnant women who are GBS carriers regardless of prior history.
These results suggest that patients with a history of GBS are at a significantly higher risk of GBS recolonization in subsequent pregnancies.
本研究旨在评估既往有B族链球菌（GBS）生殖道定植的女性在后续妊娠中再次定植的发生率。
这是一项回顾性队列研究，研究对象为2000年1月至2007年6月期间既往妊娠时有GBS生殖道定植且后续妊娠有GBS培养结果记录的患者。GBS状态的记录通过在妊娠35至37周之间进行的GBS培养。排除标准包括GBS状态不明的妊娠、GBS菌尿患者、有既往新生儿患GBS疾病的女性以及在35周之前发现GBS的女性。使用SPSS 15.0进行数据分析。计算GBS生殖道定植受试者的样本比例及其置信区间以估计发生率。进行逻辑回归以评估GBS定植的潜在决定因素。报告回归系数、比值比及相关置信区间和p值，并报告显著结果。
有371例妊娠符合测试标准。其中151例后续妊娠有GBS生殖道定植，220例无GBS再次定植。既往有GBS生殖道定植的患者中GBS再次定植的发生率为40.7%（95%置信区间35.7 - 45.69%）。样本的发生率显著高于30%（p <.001），30%是所有GBS携带者孕妇（无论既往病史如何）的估计发生率。
这些结果表明，有GBS病史的患者在后续妊娠中GBS再次定植的风险显著更高。
