Institute for Cancer Genetics, Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA.
J Clin Invest. 2012 Oct;122(10):3398-406. doi: 10.1172/JCI61269. Epub 2012 Oct 1.
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular groups of T-ALL with specific gene expression signatures and clinicobiological features. This review summarizes recent advances in our understanding of the molecular genetics of T-ALL.
T 细胞急性淋巴细胞白血病（T-ALL）是由造血祖细胞恶性转化而来，这些祖细胞已经朝着 T 细胞发育的方向成熟，是一个多步骤的致癌过程的结果，涉及 NOTCH 信号的组成性激活以及转录因子、信号转导癌基因和肿瘤抑制基因的遗传改变。值得注意的是，这些遗传改变定义了 T-ALL 的不同分子群，具有特定的基因表达特征和临床生物学特征。本文综述了我们对 T-ALL 分子遗传学认识的最新进展。
