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高三尖杉酯碱抑制 NOTCH/MYC 通路并在 T 细胞急性淋巴细胞白血病中发挥抗肿瘤作用。

Homoharringtonine inhibits the NOTCH/MYC pathway and exhibits antitumor effects in T-cell acute lymphoblastic leukemia.

机构信息

Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Hematology Malignancies Research Institute, Gehr Family Center for Leukemia Research, City of Hope Medical Center, Duarte, CA.

出版信息

Blood. 2024 Sep 19;144(12):1343-1347. doi: 10.1182/blood.2023023400.

DOI:10.1182/blood.2023023400
PMID:38968151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11451333/
Abstract

We report on the antileukemic activity of homoharringtonine (HHT) in T-cell acute lymphoblastic leukemia (T-ALL). We showed that HHT inhibited the NOTCH/MYC pathway and induced significantly longer survival in mouse and patient-derived T-ALL xenograft models, supporting HHT as a promising agent for T-ALL.

摘要

我们报告了高三尖杉酯碱（HHT）在 T 细胞急性淋巴细胞白血病（T-ALL）中的抗白血病活性。我们表明，HHT 抑制了 NOTCH/MYC 通路，并显著延长了小鼠和患者来源的 T-ALL 异种移植模型的存活时间，支持 HHT 作为一种有前途的 T-ALL 治疗药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ff/11451333/84542b44d3c8/BLOOD_BLD-2023-023400-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ff/11451333/4b86a1a2f638/BLOOD_BLD-2023-023400-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ff/11451333/84542b44d3c8/BLOOD_BLD-2023-023400-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ff/11451333/4b86a1a2f638/BLOOD_BLD-2023-023400-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28ff/11451333/84542b44d3c8/BLOOD_BLD-2023-023400-gr2.jpg

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