Hematopathology Section, Department of Hematology and Oncology L. and A. Seràgnoli, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
J Clin Invest. 2012 Oct;122(10):3448-55. doi: 10.1172/JCI61205. Epub 2012 Oct 1.
Peripheral T cell lymphomas (PTCLs) are heterogeneous neoplasms and represent about 12% of all lymphoid malignancies. They are often regarded as "orphan diseases," a designation that does not reflect their real incidence but rather signifies the difficulties encountered in their classification, diagnosis, and treatment. Here we revise the current understanding of the pathobiological characteristics of the most common nodal PTCLs by focusing on the contribution given by high-throughput technologies and the identification of potential therapeutic targets proposed by translational studies.
外周 T 细胞淋巴瘤 (PTCLs) 是异质性肿瘤，占所有淋巴恶性肿瘤的 12%左右。它们通常被视为“孤儿病”，这一名称并非反映其实际发病率，而是表明在分类、诊断和治疗方面遇到的困难。在这里，我们通过关注高通量技术的贡献和转化研究提出的潜在治疗靶点，来修订对最常见结外 PTCL 的病理生物学特征的现有认识。
