Department of Dermatological Research, Bispebjerg Hospital, Bispebjerg Bakke 23, Copenhagen 2400, Denmark.
Photochem Photobiol Sci. 2013 Jan;12(1):190-6. doi: 10.1039/c2pp25127b.
With this observation study we aimed to determine how and when sunscreen was used. 20 sun seekers were observed during a one-week sun holiday in Hurghada, Egypt. The sunscreen application thickness was related to part of body, time outdoors, exposure to ultraviolet radiation and to sunburning. Skin sites with sunscreen were exposed to UVR significantly longer and received significantly higher UVR doses than skin sites without sunscreen. They received an average of 0.62 SED [0.0-9.3 SED] (13% of their MED) before the first sunscreen application of the day. The average sunscreen used was SPF15 and the sunscreen application thickness was in average 0.79 mg cm(-)2 giving an approximated effect of SPF3. For different body parts either the total UVR exposure dose or the UVR exposure time and UVR exposure dose before the first sunscreen application were higher for sunburned than non-sunburned skin sites. In the final model gender, skin type and UVR to skin (adjusted for SPF and sunscreen application thickness) were significant predictors of sunburning. The sunscreen application thickness of 0.79 mg cm(-)2 was less than the 2 mg cm(-2) used for testing SPF. The late start of sunscreen use and improper application thickness was ineffective in preventing sunburn, and therefore could not compensate for the risk of prolonged UVR exposure and high UVR doses. Our results lead us to suspect that the protective effect of sunscreen use against DNA-damage, and thereby skin cancer, is minimal the way sunscreen is used under real sun holiday conditions.
在这项观察性研究中,我们旨在确定防晒霜的使用方式和时间。在埃及赫尔格达的一个为期一周的阳光假期中,我们观察了 20 名日光浴者。防晒霜的涂抹厚度与身体部位、户外活动时间、暴露于紫外线辐射以及晒伤有关。涂抹防晒霜的皮肤部位暴露在 UVR 下的时间明显更长,接受的 UVR 剂量也明显更高。在当天第一次涂抹防晒霜之前,他们平均接受了 0.62 SED[0.0-9.3 SED](MED 的 13%)的紫外线辐射。平均使用的防晒霜为 SPF15,防晒霜的涂抹厚度平均为 0.79mgcm(-2),近似于 SPF3 的效果。对于不同的身体部位,晒伤皮肤部位的总紫外线辐射暴露剂量或第一次涂抹防晒霜之前的紫外线辐射暴露时间和剂量均高于非晒伤皮肤部位。在最终模型中,性别、皮肤类型和紫外线辐射到皮肤(根据 SPF 和防晒霜涂抹厚度调整)是晒伤的显著预测因素。0.79mgcm(-2)的防晒霜涂抹厚度小于用于测试 SPF 的 2mgcm(-2)。防晒霜使用开始较晚且涂抹厚度不当,无法有效预防晒伤,因此无法弥补长时间暴露于紫外线辐射和高剂量紫外线辐射的风险。我们的研究结果表明,防晒霜的使用对 DNA 损伤(进而对皮肤癌)的保护作用极小,这是因为防晒霜在实际阳光假期条件下的使用方式不当。