Department of Chemistry, The University of Warwick, Coventry CV4 7AL, United Kingdom.
Org Lett. 2012 Oct 19;14(20):5230-3. doi: 10.1021/ol302354z. Epub 2012 Oct 1.
The synthesis of a series of tridentate ligands based on a homochiral 1,2-diamine structure attached to a triazole group and their subsequent applications to the asymmetric transfer hydrogenation of ketones are described. In the best cases, alcohols of up to 93% ee were obtained. Although base is not required, the use of Ru(3)(CO)(12) as metal source is essential, indicating a unique mechanism for the formation of the active catalyst.
描述了一系列基于手性 1,2-二胺结构连接三唑基团的三叉配体的合成及其随后在酮的不对称转移氢化中的应用。在最佳情况下，得到了高达 93%ee 的醇。虽然不需要碱，但使用 Ru(3)(CO)(12)作为金属源是必不可少的，这表明形成活性催化剂的独特机制。
